DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-iota and NTM

DIOPT Version :9

Sequence 1:NP_001097100.1 Gene:DIP-iota / 33925 FlyBaseID:FBgn0031837 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001338930.1 Gene:NTM / 50863 HGNCID:17941 Length:367 Species:Homo sapiens


Alignment Length:325 Identity:100/325 - (30%)
Similarity:155/325 - (47%) Gaps:44/325 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 WLLL--LQSVCFSQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQT 71
            |.:.  |.::|..|.  ..:.:.|..|...::|.||..|..|.|.|.:.:.|: :||||  :..|
Human    14 WAIFTGLAALCLFQG--VPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWL--NRST 73

  Fly    72 ILSIQNHVITKNHRISISHTEHRIWQLKIRDVQESDRGWYMCQINTD--PMKSQMGYLDVVVPPD 134
            ||...|.....:.|:.:.......:.::|::|...|.|.|.|.:.||  |..|:: :|.|.|.|.
Human    74 ILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRV-HLIVQVSPK 137

  Fly   135 IVDYQTSQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPI-LISDDGDREVFSVEGQNLTLWQ 198
            ||  :.|.|:..:.|.|::|||.|||.|.||:|||......: .:|:|   |...::|       
Human   138 IV--EISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSED---EYLEIQG------- 190

  Fly   199 VQRSHMGAYLCIASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNF 263
            :.|...|.|.|.|||.|...|.:||.:.||:.|.|.....| .|.:|||.||:|...:.|::...
Human   191 ITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGT-GVPVGQKGTLQCEASAVPSAEFQ 254

  Fly   264 WLRDSQLLQGGSYESVSVDHVFRIVMRITLRP---------ITKRDFGEYICRAKNAMGQTDRII 319
            |.:|.:.|..|. :.|.|::          ||         :::.|:|.|.|.|.|.:|.|:..|
Human   255 WYKDDKRLIEGK-KGVKVEN----------RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308

  Fly   320  319
            Human   309  308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-iotaNP_001097100.1 IG_like 39..125 CDD:214653 27/87 (31%)
Ig 39..122 CDD:299845 26/84 (31%)
Ig 132..213 CDD:299845 28/81 (35%)
IG_like 141..227 CDD:214653 31/86 (36%)
IG_like 239..322 CDD:214653 26/90 (29%)
IGc2 245..313 CDD:197706 21/76 (28%)
NTMNP_001338930.1 Ig 44..132 CDD:416386 28/91 (31%)
Ig strand A' 44..49 CDD:409353 3/4 (75%)
Ig strand B 51..59 CDD:409353 3/7 (43%)
CDR1 59..63 CDD:409353 0/3 (0%)
FR2 64..70 CDD:409353 4/8 (50%)
Ig strand C 64..70 CDD:409353 4/8 (50%)
CDR2 71..83 CDD:409353 4/11 (36%)
Ig strand C' 72..76 CDD:409353 2/3 (67%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 7/33 (21%)
Ig strand D 87..94 CDD:409353 1/6 (17%)
Ig strand E 97..103 CDD:409353 0/5 (0%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 2/3 (67%)
Ig strand G 123..132 CDD:409353 3/9 (33%)
FR4 125..132 CDD:409353 2/7 (29%)
Ig_3 136..205 CDD:404760 28/80 (35%)
Ig strand A' 142..147 CDD:409353 2/4 (50%)
Ig strand B 153..160 CDD:409353 3/6 (50%)
Ig strand C 166..171 CDD:409353 3/4 (75%)
Ig strand D 177..180 CDD:409353 0/2 (0%)
Ig strand E 184..190 CDD:409353 1/5 (20%)
Ig strand F 197..204 CDD:409353 3/6 (50%)
Ig strand G 211..219 CDD:409353 3/7 (43%)
Ig_3 222..299 CDD:404760 24/88 (27%)
putative Ig strand A 223..229 CDD:409353 2/5 (40%)
Ig strand B 239..243 CDD:409353 2/3 (67%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 0/3 (0%)
Ig strand F 292..297 CDD:409353 2/4 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143469
Domainoid 1 1.000 59 1.000 Domainoid score I10656
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 141 1.000 Inparanoid score I4481
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - mtm8497
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.800

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