DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and NCAM2

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	298	Identity:	80/298 - (26%)
Similarity:	127/298 - (42%)	Gaps:	33/298 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NSDPKFSGPIN--NSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISI-- 88
            |..|..|.|..  |:|...|.:...:|.........::|.|         ...:|.:|.:..:
Human   231 NVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFR---------NGKLIEENEKYILKG 286

  Fly    89 SHTEHRIWQLKIRDVQESDRGWYMCQ-INTDPMKSQMGYLDVVVPPDIVDYQTSQDVVRSTGQNV 152
            |:||     |.:|::..||.|.|:|: .|......:..:|.|.|.|.|:  |...:.....|| |
Human   287 SNTE-----LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII--QLKNETTYENGQ-V 343

  Fly   153 TLTCSATGVPMPTITWRREEATPILISDDGDREV---FSVEGQ----NLTLWQVQRSHMGAYLCI 210
            ||.|.|.|.|:|.|||:|  |.......:||:.:   ..|:||    :|.:..|:.|..|.|.|.
Human   344 TLVCDAEGEPIPEITWKR--AVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 406

  Fly   211 ASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNFWLRDSQLLQGGS 275
            |::.:... .|.:.|.:.:||...:.....|...|..:.:.|..:|.|.:...|.||..:|...:
Human   407 AASRIGGH-QKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 470

  Fly   276 YESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMG 313
            ..::......| .|.:.:.|.:..|||.|.|.|.|.:|
Human   471 TTNLKTYSTGR-KMILEIAPTSDNDFGRYNCTATNHIG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	19/88 (22%)
		Ig	39..122	CDD:299845	19/85 (22%)
		Ig	132..213	CDD:299845	30/87 (34%)
		IG_like	141..227	CDD:214653	29/92 (32%)
		IG_like	239..322	CDD:214653	20/75 (27%)
		IGc2	245..313	CDD:197706	18/67 (27%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274
		I-set	47..136	CDD:254352
		I-set	142..218	CDD:254352
		IGc2	153..214	CDD:197706
		Ig	233..326	CDD:299845	24/106 (23%)
		I-set	240..323	CDD:254352	20/96 (21%)
		Ig5_NCAM-2	325..422	CDD:143278	33/102 (32%)
		IG_like	333..420	CDD:214653	28/90 (31%)
		IG_like	438..515	CDD:214653	19/71 (27%)
		IGc2	439..507	CDD:197706	18/68 (26%)
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810