DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and negr1

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	324	Identity:	93/324 - (28%)
Similarity:	153/324 - (47%)	Gaps:	36/324 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WL--LLLQSVCFSQASFSELNNSDPKFSGPINNSTVP-VGRDALLTCVVHDLVSFKVAWLRVDTQ 70
            ||  ::|...||..:........|...|   :.|.|. .|..|||.|.:.|.:| |.|||  :..
Zfish    16 WLTAIILSLCCFLPSCLPAGQTVDYTTS---SESVVSRQGDTALLRCYLLDGIS-KGAWL--NRS 74

  Fly    71 TILSIQNHVITKNHRISISHT---EHRIWQLKIRDVQESDRGWYMCQINTD-PMKSQMGYLDVVV 131
            :|:...|...:.:.|:||...   :|. :.|:|:.|..:|.|.|.|.|.:: .:..::..|.|.|
Zfish    75 SIIYAGNDKWSGDPRVSIVSNVGDKHE-YSLQIQKVDVTDEGVYTCSIQSERNLHPKLIQLIVKV 138

  Fly   132 PPDIVDYQTSQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTL 196
            ||.|  |..|.|:..:.|.||:|.|:|:|.|.|.|:||.       ||... |:..|  |:.|.:
Zfish   139 PPKI--YDISSDITVNEGSNVSLICAASGKPEPKISWRH-------ISPSA-RKYES--GEYLNI 191

  Fly   197 WQVQRSHMGAYLCIASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGL--GQKLTLECITESQPA 259
            ..:.|...|.|.|.|.|.:....:|.|.:.|||.|.|   ::....|:  ||...|.|...:.|:
Zfish   192 TGISRDQAGDYECGAENDIASPDTKTVRVTVNFPPAI---HEMKSHGVRPGQVALLRCEAAAVPS 253

  Fly   260 SVNFWLRDSQLLQGGSYESVSVDHV-FRIVMRITLRPITKRDFGEYICRAKNAMGQTDRIITVH 322
            .|..|.:..:.:..|  :.:.:::: .|.|  :|::.:|:..:|.|.|.|.|.:|..:..:.::
Zfish   254 PVFEWYKGEKRINMG--QGIVINNLSSRSV--LTVKNMTQDRYGNYTCVAVNRLGTANASVPLN 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	27/90 (30%)
		Ig	39..122	CDD:299845	27/87 (31%)
		Ig	132..213	CDD:299845	29/80 (36%)
		IG_like	141..227	CDD:214653	28/85 (33%)
		IG_like	239..322	CDD:214653	19/85 (22%)
		IGc2	245..313	CDD:197706	17/68 (25%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	27/85 (32%)
		IG_like	44..136	CDD:214653	28/95 (29%)
		I-set	140..222	CDD:254352	31/93 (33%)
		IGc2	153..208	CDD:197706	23/64 (36%)
		IG_like	236..312	CDD:214653	18/79 (23%)
		IGc2	238..304	CDD:197706	17/69 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576333
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750