DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and LSAMP

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	407	Identity:	115/407 - (28%)
Similarity:	169/407 - (41%)	Gaps:	93/407 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RRLPSFWLLLLQSVCFSQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRV 67
            ::||   |:||:.:|...... .:.:.|  |:...:|.||..|..|:|.|||.|..| |||||.
Human    10 KQLP---LVLLRLLCLLPTGL-PVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNS-KVAWLN- 66

  Fly    68 DTQTILSIQNHVITKNH-------RISISHTEHRIWQLKIRDVQESDRGWYMCQINT--DPMKSQ 123
                    ::.:|...|       |:.:.......:.|:|:.|...|.|.|.|.:.|  :|..||
Human    67 --------RSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQ 123

  Fly   124 MGYLDVVVPPDIVDYQTSQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPILISDDGDREVFS 188
            : ||.|.|||.|.:  .|.||..:.|.||||.|.|.|.|.|.||||  ..||.....:|:.|...
Human   124 V-YLIVQVPPKISN--ISSDVTVNEGSNVTLVCMANGRPEPVITWR--HLTPTGREFEGEEEYLE 183

  Fly   189 VEGQNLTLWQVQRSHMGAYLCIASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECI 253
            :.|       :.|...|.|.|.|:|.|.....|:|.:.||:.||| |...:.....|::.:|:|.
Human   184 ILG-------ITREQSGKYECKAANEVSSADVKQVKVTVNYPPTI-TESKSNEATTGRQASLKCE 240

  Fly   254 TESQPASVNFWLRDSQLLQGG------SYESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAM 312
            ..:.||....|.||...:...      |.|..|         .:|:..:|:..:|.|.|.|.|.:
Human   241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQS---------SLTVTNVTEEHYGNYTCVAANKL 296

  Fly   313 GQTD-------RII------------TVHHKAKKHGQHSHQTSSRESQFIVIEEYIANMSDKSCS 358
            |.|:       |::            |||.|.|..|.                  :..::.....
Human   297 GVTNASLVLFKRVLPTIPHPIQEIGTTVHFKQKGPGS------------------VRGINGSISL 343

  Fly   359 FQPLWIM---FLCFVNK 372
            ..|||::   .||.::|
Human   344 AVPLWLLAASLLCLLSK 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	30/94 (32%)
		Ig	39..122	CDD:299845	28/91 (31%)
		Ig	132..213	CDD:299845	30/80 (38%)
		IG_like	141..227	CDD:214653	31/85 (36%)
		IG_like	239..322	CDD:214653	22/107 (21%)
		IGc2	245..313	CDD:197706	18/73 (25%)
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	32/100 (32%)
		Ig	132..215	CDD:386229	33/93 (35%)
		Ig_3	219..294	CDD:372822	21/84 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143414
Domainoid	1	1.000	59	1.000	Domainoid score	I10656
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.800