DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-iota and Strn-Mlck

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	82/353 - (23%)
Similarity:	136/353 - (38%)	Gaps:	73/353 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISISHTEHRIWQLKIRDVQESDR 108
            :|....|.|.:......:|.|.:...|        :.:.:.|:.|....... .|.|..|.|.|.
  Fly  6335 LGSSFTLQCNMRGAPRPQVTWFKDGIQ--------LSSSSERVKIRQIGSTC-ALTIATVSELDS 6390

  Fly   109 GWYMCQ-INTDPMKSQMGYLDVVVPPDIVDYQTSQDVVRSTGQNVT------------------- 153
            |.|.|: .|:....|....|.||....|.:..:....: :.|:||.
  Fly  6391 GRYTCEATNSKGRVSTFARLQVVSDSRIYEADSRLKEI-AHGRNVADVGDSLPIFTMRLRDRRVQ 6454

  Fly   154 ------LTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTLWQVQRSHM---GAYLC 209
                  |||...|.|:|.|.|.:::.   ||..| .:.:.|.|||..|| ::..:.:   |.|.|
  Fly  6455 VTYPVRLTCQIVGYPVPEILWYKDDE---LIHTD-RKHLISAEGQFFTL-EIAATTLDDSGTYTC 6514

  Fly   210 IASNGVPPTVSKRVMLVVN------FAPTIWTRYDTIYV-GLGQKLTLECITESQPASVNFWLRD 267
            :|.|.: .:||....|||:      .:|..:...|..|: ..|.::.|....|:.|:....|.|:
  Fly  6515 LARNEL-GSVSCHCTLVVDKGIRAYISPDFYVPLDPFYIFREGSEIRLSTKVEAYPSVGVTWHRN 6578

  Fly   268 SQLLQGGSYESVSVD---HVFRIVMRITLRPITKRDFGEYICRAKNAMGQTDRIITVHHKAKKHG 329
            ...|:.....:.::|   :|..|:...|:     ||.|.|:|.|.|.:|:.:.|..|..:..::.
  Fly  6579 GMRLRPSRRLTATLDSNGYVELIIAEATV-----RDAGIYVCVASNVVGKVETICRVAVEEAENK 6638

  Fly   330 QHSHQTS-------------SRESQFIV 344
            ..:.|.|             |:|..|:|
  Fly  6639 AVAPQRSLEIPSIKTDDLPYSKEPLFVV 6666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	18/81 (22%)
		Ig	39..122	CDD:299845	17/78 (22%)
		Ig	132..213	CDD:299845	25/108 (23%)
		IG_like	141..227	CDD:214653	28/113 (25%)
		IG_like	239..322	CDD:214653	21/86 (24%)
		IGc2	245..313	CDD:197706	18/70 (26%)
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352	19/85 (22%)
		Ig	6328..6412	CDD:299845	19/85 (22%)
		I-set	6442..6531	CDD:254352	25/94 (27%)
		Ig	6459..6528	CDD:143165	24/74 (32%)
		I-set	6541..6632	CDD:254352	24/95 (25%)
		IGc2	6555..6622	CDD:197706	18/71 (25%)
		I-set	6662..6754	CDD:254352	2/5 (40%)
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910