DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and Dscam1

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	367	Identity:	88/367 - (23%)
Similarity:	127/367 - (34%)	Gaps:	111/367 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISISHTEHRIWQLKIRDVQE 105
            ||..||.|:.||.........|:|:: |.:                :|.|:|.   .|:|..|::
  Fly   357 TVDFGRPAVFTCQYTGNPIKTVSWMK-DGK----------------AIGHSEP---VLRIESVKK 401

  Fly   106 SDRGWYMCQINTDPMKSQM-------GYLDVVVPPDIVDYQTSQDVVRSTGQNVTLTCSATGVPM 163
            .|:|.|.|.:..|...::.       |..|   ||  |..|..|:.....|.:|.|.|.|.|.|.
  Fly   402 EDKGMYQCFVRNDQESAEASAELKLGGRFD---PP--VIRQAFQEETMEPGPSVFLKCVAGGNPT 461

  Fly   164 PTITWRREEATPILISDDG------DR----EVFSVEG---QNLTLWQVQRSHMGAYLCIASN-- 213
            |.|:|..          ||      ||    :..:|.|   ..|.:..|..:..|.|.|||.:
  Fly   462 PEISWEL----------DGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKV 516

  Fly   214 GVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNFWLRDSQLLQGGSYES 278
            ||....:|   |.|...|.| .:.:...:..|:.|.:.|.....|.....|.||::.|.....:.
  Fly   517 GVAEHSAK---LNVYGLPYI-RQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQK 577

  Fly   279 V------SVDHVFRIVMRITLRPITKRDFGEYICRAKNAMGQTDRIITVHHKAKKHGQHSHQTSS 337
            |      .:::|.|           ..|...|.|.|||..|.:.|                  .|
  Fly   578 VFPNGTLIIENVER-----------NSDQATYTCVAKNQEGYSAR------------------GS 613

  Fly   338 RESQFIVIE-------EYIANMSDKSCSFQPLWIMFLCFVNK 372
            .|.|.:|:.       |.:.||.|.        |...|.:.|
  Fly   614 LEVQVMVLPQIVPFAYEDLINMGDS--------IDLFCQIQK 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	21/90 (23%)
		Ig	39..122	CDD:299845	21/80 (26%)
		Ig	132..213	CDD:299845	28/93 (30%)
		IG_like	141..227	CDD:214653	28/100 (28%)
		IG_like	239..322	CDD:214653	19/88 (22%)
		IGc2	245..313	CDD:197706	17/73 (23%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	21/87 (24%)
		IGc2	361..413	CDD:197706	18/71 (25%)
		I-set	433..527	CDD:254352	31/108 (29%)
		IGc2	446..517	CDD:197706	23/80 (29%)
		I-set	533..618	CDD:254352	22/114 (19%)
		IGc2	544..607	CDD:197706	17/73 (23%)
		Ig	641..714	CDD:143165	2/7 (29%)
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900