DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	135/341 - (39%)
Similarity:	196/341 - (57%)	Gaps:	24/341 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLLQSVCFS---QASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDL-----------VSF 60
            ||||...|..   ....|.:...:|.|..|:.|.|:..||||..||||::|           ...
  Fly    74 LLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPA 138

  Fly    61 KVAWLRVDTQTILSIQNHVITKNHRISISHTEHRIWQLKIRDVQESDRGWYMCQINTDPMKSQMG 125
            ||||::.|.:.||:|..||||.|.|:|:.|.::..|.|.||.|:..|.|.||||:||||||.|..
  Fly   139 KVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTA 203

  Fly   126 YLDVVVPPDIVDYQTSQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPILISDDGDRE---VF 187
            .|:||:||||::.:||.|::...|.:..|.|.|.|.|.|.||||||:...| |:.:|..:   ..
  Fly   204 TLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREI-IARNGSHQKTKAQ 267

  Fly   188 SVEGQNLTLWQVQRSHMGAYLCIASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLEC 252
            ||||:.|||.::.||.||||:||||||||||||||:.|.|:|.|.:......:...:...:||.|
  Fly   268 SVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLIC 332

  Fly   253 ITESQPASVNFWLRDS--QLLQGGSYE-SVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMGQ 314
            ..|:.|.::|:|.|::  .::.|..|. :...::::.|.|.:.::.:...|||.|.|.:||::|.
  Fly   333 NVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGD 397

  Fly   315 TD---RIITVHHKAKK 327
            |:   |:..:....||
  Fly   398 TEGTIRLYEMERPGKK 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	45/96 (47%)
		Ig	39..122	CDD:299845	43/93 (46%)
		Ig	132..213	CDD:299845	39/83 (47%)
		IG_like	141..227	CDD:214653	46/88 (52%)
		IG_like	239..322	CDD:214653	22/88 (25%)
		IGc2	245..313	CDD:197706	19/70 (27%)
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	50/110 (45%)
		ig	102..195	CDD:278476	39/92 (42%)
		IG_like	219..307	CDD:214653	46/88 (52%)
		Ig	221..307	CDD:299845	45/86 (52%)
		Ig	311..404	CDD:299845	22/92 (24%)
		IG_like	327..405	CDD:214653	22/77 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442812
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	9	8.800