DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001101611.1	Gene:	Dscaml1 / 315615	RGDID:	1304887	Length:	2111	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	93/352 - (26%)
Similarity:	141/352 - (40%)	Gaps:	60/352 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNH--VITKNHRI 86
            :.:|...|.....:.|.|...|||.|:.|.|.....:.:.|.:   ..:|...||  |:.:|
  Rat   556 ARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK---DALLLPDNHRQVVFEN--- 614

  Fly    87 SISHTEHRIWQLKIRDVQES-DRGWYMCQINTDPMK--SQMGYLDVVVPPDIVDYQTSQDVVRST 148
                     ..||:.|||:. |.|.|:|.:...|..  ||..::.|.|||.|..::...   .|.
  Rat   615 ---------GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP---ASI 667

  Fly   149 GQNVTLTCSATGVPMP-TITWRREEATPILISDDG----DREVFSVEGQNLTLWQVQRSHMGAYL 208
            ||.:.:.|..:...|| .||||::  ..::||..|    .:|..|    :|.:..|...|.|.|.
  Rat   668 GQLLYIPCVVSSGDMPIRITWRKD--GQVIISGSGVTIESKEFMS----SLQISSVSLKHNGNYT 726

  Fly   209 CIASNGVPPTVSKRVMLVVNFAPTIWTR---YDTIYVGLGQKLTLECITESQPASVNFWLRDSQL 270
            |||||.. .|||:...|:|...|....:   .|.||   |:...|.|..:..|.....|......
  Rat   727 CIASNAA-ATVSRERQLIVRVPPRFVVQPNNQDGIY---GKAGVLNCSVDGYPPPKVMWKHAKGS 787

  Fly   271 LQGGSYESVSVDHVFRIV--MRITLRPITKRDFGEYICRAKNAMGQTD------------RIITV 321
            .....|..|.:....:|:  ..:.:|.:.:.|.|.|:|:|.|.:| ||            .:||.
  Rat   788 GNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG-TDISKAMFLTVKIPAMITS 851

  Fly   322 HHKA----KKHGQHSHQTSSRESQFIV 344
            |...    |.|.:..:.|:..|...|:
  Rat   852 HPNTTIAIKGHAKELNCTARGERPIII 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	26/90 (29%)
		Ig	39..122	CDD:299845	24/87 (28%)
		Ig	132..213	CDD:299845	26/85 (31%)
		IG_like	141..227	CDD:214653	29/90 (32%)
		IG_like	239..322	CDD:214653	22/96 (23%)
		IGc2	245..313	CDD:197706	15/69 (22%)
Dscaml1	NP_001101611.1	IG	101..173	CDD:214652
		IGc2	101..168	CDD:197706
		Ig	183..276	CDD:299845
		IG_like	195..276	CDD:214653
		I-set	291..369	CDD:254352
		IGc2	298..359	CDD:197706
		IGc2	386..447	CDD:197706
		I-set	466..560	CDD:254352	0/3 (0%)
		Ig	466..556	CDD:299845	93/352 (26%)
		IGc2	577..635	CDD:197706	21/72 (29%)
		IG_like	665..744	CDD:214653	29/85 (34%)
		Ig	673..739	CDD:143165	25/72 (35%)
		I-set	748..843	CDD:254352	22/98 (22%)
		Ig7_DSCAM	765..843	CDD:143211	17/78 (22%)
		I-set	849..942	CDD:254352	8/30 (27%)
		Ig	861..949	CDD:299845	4/18 (22%)
		FN3	945..1039	CDD:238020
		FN3	1046..1143	CDD:238020
		fn3	1151..1237	CDD:278470
		FN3	1249..1340	CDD:238020
		IGc2	1364..1428	CDD:197706
		FN3	1442..1532	CDD:238020
		FN3	1546..1618	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810