DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	140/378 - (37%)
Similarity:	208/378 - (55%)	Gaps:	43/378 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLLQSVCFSQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILS 74
            |||:.|:..:..:|      .|:|...|:|.:|.|||||..||.|..|..::|.||:.||:.|.:
  Fly    27 LLLIVSLLEAIGAF------QPEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQA 85

  Fly    75 IQNHVITKNHRISISHTEHRIWQLKIRDVQESDRGWYMCQINTDPMKSQMGYLDVVVPPDIVDYQ 139
            |..:|||.|.|:::||.:...|.|.|:.|.|.|||.||||:||||||||:|:||||:|||.:...
  Fly    86 IHENVITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVIPPDFISED 150

  Fly   140 TSQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPILISDDGDREVF--SVEGQNLTLWQVQRS 202
            ||.||:...|.:|.|||.|.|.|.|.:|||||:...|::.|:...:..  |..|:.|.|.::.|:
  Fly   151 TSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRN 215

  Fly   203 HMGAYLCIASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNFWLRD 267
            .||:|||||||||||:||||:.|.::|.|.|......:...||..:.:||..|:.|.|:|:|::|
  Fly   216 EMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKD 280

  Fly   268 S--QLLQGGSYE-SVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMGQTDRIITVHH------ 323
            :  .::..|.|. ..|...::...|.:.:|...|.|.|.|.|.|||::|:.|..|.::.
  Fly   281 TGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGPNR 345

  Fly   324 --------------------------KAKKHGQHSHQTSSRESQFIVIEEYIA 350
                                      |.|:..:.::|....|.|:..:|::.|
  Fly   346 NKNPLNGGGKGGGAGGSLDADANDILKQKQQVKVTYQPEDEELQYGSVEDFEA 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	45/85 (53%)
		Ig	39..122	CDD:299845	42/82 (51%)
		Ig	132..213	CDD:299845	35/82 (43%)
		IG_like	141..227	CDD:214653	42/87 (48%)
		IG_like	239..322	CDD:214653	26/85 (31%)
		IGc2	245..313	CDD:197706	22/70 (31%)
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	38/79 (48%)
		Ig	51..131	CDD:299845	39/79 (49%)
		I-set	144..240	CDD:254352	45/95 (47%)
		IGc2	159..228	CDD:197706	30/68 (44%)
		Ig	244..337	CDD:299845	28/92 (30%)
		I-set	244..337	CDD:254352	28/92 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12510
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	7	6.870