DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-iota and Lrit1

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	314	Identity:	66/314 - (21%)
Similarity:	111/314 - (35%)	Gaps:	102/314 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 CVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHR----ISISHTEHRIWQLKIRDVQESDRGWYM 112
            |.::|||.....|    ...::.|:..:...:.|    ::.|       ||::|..|.
  Rat   207 CRLYDLVHLLDGW----ASNLIFIEARLRCGSPRSLAGVAFS-------QLELRKCQS------- 253

  Fly   113 CQINTDPMKSQMGYLDVVVPPDIVDYQTSQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPIL 177
                                |::....||  ::...|..|.|.|.|||:|.|.::|||....|
  Rat   254 --------------------PELRPGVTS--IISPLGSTVLLRCGATGIPGPEMSWRRANGRP-- 294

  Fly   178 ISDDGDREVFSVEGQNLTLWQ---VQRSHMGAYLCIASN--GVPPTVSKRVMLVVNFAPTIWTRY 237
            ::....:|| |.:|.:.||..   |.....|.|:|.|.|  |...|:   :.|:|....|
  Rat   295 LNGTVHQEV-SSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETL---ISLIVTEPQT----- 350

  Fly   238 DTIYVGLGQKLTLECITESQPASVNFWLRDSQLLQGGSYESVSV-DHVFRIVMRITLR-----PI 296
            .|.|.|:             |.::  |.|..:..:..:|.:..| .||..:...:.|.     |.
  Rat   351 STEYTGI-------------PGAL--WARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVPS 400

  Fly   297 TKRDF----------GEY-----------ICRAKNAMGQTDRIITVHHKAKKHG 329
            .|.:.          ||:           :.|:...:|.|...:::..||.:.|
  Rat   401 IKEELPLQNFQMDVPGEFSREPSEHQETQMVRSLKVVGDTYHSVSLVWKAPQAG 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	12/76 (16%)
		Ig	39..122	CDD:299845	12/73 (16%)
		Ig	132..213	CDD:299845	27/83 (33%)
		IG_like	141..227	CDD:214653	29/90 (32%)
		IG_like	239..322	CDD:214653	18/109 (17%)
		IGc2	245..313	CDD:197706	13/94 (14%)
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..128
		LRR_8	131..>176	CDD:290566
		LRR_4	131..172	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>240	CDD:301599	7/36 (19%)
		Ig	257..345	CDD:299845	30/95 (32%)
		IG_like	267..345	CDD:214653	28/83 (34%)
		FN3	431..501	CDD:214495	6/24 (25%)
		LRR 6	525..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900