DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	327	Identity:	80/327 - (24%)
Similarity:	120/327 - (36%)	Gaps:	53/327 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLQSVCFSQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVV---HDLVSFKVAWLRVDTQTI 72
            ||:...||...:     .|.|.|.....:..|.:|.:|.|.|.:   ..||.:....|.:..:..
Mouse     6 LLVFLCCFKGHA-----GSSPHFLQQPEDMVVLLGEEARLPCALGAYRGLVQWTKDGLALGGERD 65

  Fly    73 LSIQNHVITKNHRISISHTEHRIWQLKIRDVQESDRGWYMCQINTDPMKSQMGYLDVVVPPDIVD 137
            |...:......:..|..|..|      |:.|:..|...|.||.:...::|:...|.|:|||:...
Mouse    66 LPGWSRYWISGNSASGQHDLH------IKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQ 124

  Fly   138 YQTSQDVVRSTGQNVTLTCSATG--VPMPTITWRREEATPILISDDG---------DREVFSVEG 191
            ......|....|....|||.:.|  .|.|.:.|.|:.     |..||         |:...:||.
Mouse   125 VLGGPSVSLVAGVPGNLTCRSRGDSRPAPELLWFRDG-----IRLDGSSFHQTTLKDKATGTVEN 184

  Fly   192 QNLTLWQVQRSH-MGAYL-CIA-SNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECI 253
               ||:....|| .||.| |.| |..:|......|.|.:.:.|.:....:...|..|:|:|..|.
Mouse   185 ---TLFLTPSSHDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQ 246

  Fly   254 TESQPASVNF-WLRDSQLLQG--GSYESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMGQT 315
            ..:||....: |.:....:.|  |....|..|..|      ...|::        |...||:|..
Mouse   247 ATAQPPVTGYRWAKGGSPVLGARGPRLEVVADATF------LTEPVS--------CEVSNAVGSA 297

  Fly   316 DR 317
            :|
Mouse   298 NR 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	19/88 (22%)
		Ig	39..122	CDD:299845	18/85 (21%)
		Ig	132..213	CDD:299845	27/94 (29%)
		IG_like	141..227	CDD:214653	29/99 (29%)
		IG_like	239..322	CDD:214653	19/82 (23%)
		IGc2	245..313	CDD:197706	16/70 (23%)
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	20/94 (21%)
		Ig	122..220	CDD:416386	29/105 (28%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	1/3 (33%)
		Ig strand B	140..147	CDD:409353	3/6 (50%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	0/6 (0%)
		Ig strand D	166..173	CDD:409353	1/6 (17%)
		Ig strand E	180..188	CDD:409353	4/10 (40%)
		Ig strand F	197..205	CDD:409353	4/7 (57%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	16/82 (20%)
		Ig strand B	241..245	CDD:409353	1/3 (33%)
		Ig strand C	255..259	CDD:409353	0/3 (0%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	3/22 (14%)
		Ig strand G	298..301	CDD:409353	1/2 (50%)
		Ig	315..392	CDD:416386
		Ig strand A'	316..321	CDD:409353
		Ig strand B	324..333	CDD:409353
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810