DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-iota and SDK1

DIOPT Version :9

Sequence 1:NP_001097100.1 Gene:DIP-iota / 33925 FlyBaseID:FBgn0031837 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:354 Identity:80/354 - (22%)
Similarity:133/354 - (37%) Gaps:69/354 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 PINNSTVPVGRDALLTCV-----VHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISISHTEHRI 95
            |.|.|.|....:..|.|:     |.||   .|.|                 |.:.:.|:...|..
Human   299 PGNRSVVAGSSETTLECIASARPVEDL---SVTW-----------------KRNGVRITSGLHSF 343

  Fly    96 W-QLKIRDVQESDRGWYMCQINT-----DPMKSQMGYLDVVVPPDIVDYQTSQDVVRSTG---QN 151
            . :|.|.:...:|.|.|:|:...     :|.:: ..:|.::.||    |.|::...|.:.   :.
Human   344 GRRLTISNPTSADTGPYVCEAALPGSAFEPARA-TAFLFIIEPP----YFTAEPESRISAEVEET 403

  Fly   152 VTLTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTLWQVQRSHMGAYLCIASNGVP 216
            |.:.|.|.|||:||:.|.: :|..|....:...:|.:..|  |.:.:::....|.:.|.|||...
Human   404 VDIGCQAMGVPLPTLQWYK-DAISISRLQNPRYKVLASGG--LRIQKLRPEDSGIFQCFASNEGG 465

  Fly   217 PTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNFWLRDSQLLQGGSYESVSV 281
            ...:...:.|.|.||....|.....|..|....|.|.....|.....|.|::.:|..||.     
Human   466 EIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSV----- 525

  Fly   282 DHVFRIVM----RITLRPITKRDFGEYICRAKNAMG--QTDRIITVHHKAK-KHGQHSHQTSSRE 339
             .:.|.::    .:.:.|:..:|.|.|.|.|.|..|  .....:||.::.. .|....|      
Human   526 -RIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDH------ 583

  Fly   340 SQFIVIEEYIANM-----SDKSCSFQPLW 363
               :||:...|.:     .|...|.:.:|
Human   584 ---VVIKGTTATLHCGATHDPRVSLRYVW 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-iotaNP_001097100.1 IG_like 39..125 CDD:214653 19/96 (20%)
Ig 39..122 CDD:299845 19/93 (20%)
Ig 132..213 CDD:299845 22/83 (27%)
IG_like 141..227 CDD:214653 20/88 (23%)
IG_like 239..322 CDD:214653 20/88 (23%)
IGc2 245..313 CDD:197706 17/71 (24%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706 16/71 (23%)
I-set 386..475 CDD:254352 23/95 (24%)
Ig 404..472 CDD:143165 19/70 (27%)
I-set 480..570 CDD:254352 21/95 (22%)
Ig 494..570 CDD:299845 18/81 (22%)
I-set 575..664 CDD:254352 8/44 (18%)
Ig 580..664 CDD:299845 7/39 (18%)
FN3 668..759 CDD:238020
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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