DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and Papln

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	256	Identity:	68/256 - (26%)
Similarity:	98/256 - (38%)	Gaps:	53/256 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PDIVDYQTSQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTLW 197
            |.:||        .|.||.:.|||.|.|.|:|||.|:|:..   |:|  ..|.....:| :|.:.
Mouse  1072 PGVVD--------ASPGQRIRLTCRAEGFPVPTIEWQRDGQ---LVS--SPRHQVQPDG-SLVIS 1122

  Fly   198 QVQRSHMGAYLCIASNGVPPT---VSKRVM--LVVNFAPTIWTRYDTIYVGLGQKLTLECITESQ 257
            :|.....|.|.|:|.||....   |..||:  |.:...|      ..:.|..|....|.|:...:
Mouse  1123 RVDVEDGGYYSCVAFNGQDRDQRWVQLRVLRELTITGLP------PAVTVAEGDTARLLCVVAGE 1181

  Fly   258 PASVNF-WLRDSQLLQG-GSYESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMGQTDRIIT 320
              |||. |.|:...:|. |.....|.|....|   ..|||   ||.|.|.|.|........|...
Mouse  1182 --SVNIRWSRNGLPIQADGHRVHQSPDGTLLI---HNLRP---RDEGSYTCSAFRGSQAVSRSTE 1238

  Fly   321 VH-------HKAKKHGQHSHQTSSRESQFIVIE------EYIANMSDKSCS-----FQPLW 363
            |.       .:::..|:.........:..::::      ||.::....|||     .||:|
Mouse  1239 VKVALPAPAAQSRDLGKDCIDQPELANCALILQAQLCGNEYYSSFCCASCSRFQPNAQPVW 1299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653
		Ig	39..122	CDD:299845
		Ig	132..213	CDD:299845	27/79 (34%)
		IG_like	141..227	CDD:214653	30/90 (33%)
		IG_like	239..322	CDD:214653	24/84 (29%)
		IGc2	245..313	CDD:197706	22/69 (32%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064
		I-set	1070..1141	CDD:369462	29/82 (35%)
		Ig	1157..1241	CDD:386229	26/97 (27%)
		PLAC	1257..1289	CDD:370061	3/31 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900