DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	352	Identity:	93/352 - (26%)
Similarity:	141/352 - (40%)	Gaps:	60/352 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNH--VITKNHRI 86
            :.:|...|.....:.|.|...|||.|:.|.|.....:.:.|.:   ..:|...||  |:.:|
Mouse   498 ARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK---DALLLPDNHRQVVFEN--- 556

  Fly    87 SISHTEHRIWQLKIRDVQES-DRGWYMCQINTDPMK--SQMGYLDVVVPPDIVDYQTSQDVVRST 148
                     ..||:.|||:. |.|.|:|.:...|..  ||..::.|.|||.|..::...   .|.
Mouse   557 ---------GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP---ASI 609

  Fly   149 GQNVTLTCSATGVPMP-TITWRREEATPILISDDG----DREVFSVEGQNLTLWQVQRSHMGAYL 208
            ||.:.:.|..:...|| .||||::  ..::||..|    .:|..|    :|.:..|...|.|.|.
Mouse   610 GQLLYIPCVVSSGDMPIRITWRKD--GQVIISGSGVTIESKEFMS----SLQISSVSLKHNGNYT 668

  Fly   209 CIASNGVPPTVSKRVMLVVNFAPTIWTR---YDTIYVGLGQKLTLECITESQPASVNFWLRDSQL 270
            |||||.. .|||:...|:|...|....:   .|.||   |:...|.|..:..|.....|......
Mouse   669 CIASNAA-ATVSRERQLIVRVPPRFVVQPNNQDGIY---GKAGVLNCSVDGYPPPKVMWKHAKGS 729

  Fly   271 LQGGSYESVSVDHVFRIV--MRITLRPITKRDFGEYICRAKNAMGQTD------------RIITV 321
            .....|..|.:....:|:  ..:.:|.:.:.|.|.|:|:|.|.:| ||            .:||.
Mouse   730 GNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG-TDISKAMFLTVKIPAMITS 793

  Fly   322 HHKA----KKHGQHSHQTSSRESQFIV 344
            |...    |.|.:..:.|:..|...|:
Mouse   794 HPNTTIAIKGHPKELNCTARGERPIII 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	26/90 (29%)
		Ig	39..122	CDD:299845	24/87 (28%)
		Ig	132..213	CDD:299845	26/85 (31%)
		IG_like	141..227	CDD:214653	29/90 (32%)
		IG_like	239..322	CDD:214653	22/96 (23%)
		IGc2	245..313	CDD:197706	15/69 (22%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706
		Ig	125..218	CDD:353325
		I-set	226..311	CDD:336764
		Ig_3	317..389	CDD:339005
		Ig	408..498	CDD:353325	93/352 (26%)
		IGc2	519..577	CDD:197706	21/72 (29%)
		Ig	615..681	CDD:319273	25/72 (35%)
		Ig_DSCAM	707..785	CDD:143211	17/78 (22%)
		Ig	803..891	CDD:353325	4/18 (22%)
		FN3	887..981	CDD:238020
		FN3	988..1085	CDD:238020
		FN3	1093..1186	CDD:238020
		FN3	1191..1282	CDD:238020
		Ig	1307..1377	CDD:319273
		FN3	1384..1474	CDD:238020
		FN3	1488..1560	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810