DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-iota and ncam1b

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_005157462.1	Gene:	ncam1b / 114442	ZFINID:	ZDB-GENE-010822-2	Length:	1055	Species:	Danio rerio

Alignment Length:	332	Identity:	89/332 - (26%)
Similarity:	131/332 - (39%)	Gaps:	67/332 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISISHTEHRIWQLKIRDV 103
            |:|..:|...||.|.........|.|.|         .|..:...::.|.:....   ::.:.||
Zfish   219 NATADMGFSTLLACDPDGFPEPIVTWRR---------NNAPLESGNKYSFNEDGS---EMTVLDV 271

  Fly   104 QESDRGWYMCQINTDPMKSQMGY-LDVVVPPDI--VDYQTSQDVVRSTGQNVTLTCSATGVPMPT 165
            .:.|.|.|.|.......:|:... |.|.|.|.|  ::.||:.::    .:.|||||.|||.|.||
Zfish   272 TKLDEGDYTCIAKNKAGESEQELSLKVFVQPKITYLESQTTTEM----DEQVTLTCEATGDPTPT 332

  Fly   166 ITW----------RREEATPILISD----------DGDREVFS-VEGQNLTLWQVQRSHMGAYLC 209
            |||          .:|:...|..:.          ||:..|.| ....:|||...|.:..|.|||
Zfish   333 ITWSFGTRVFTEGEQEQQKRIYQASWTRPEQHKGPDGEVLVRSDARVSSLTLKYPQYTDAGQYLC 397

  Fly   210 IASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNF-WLRDSQLLQG 273
            .|.|.:..|| :.|.|.|.:||.|.... .:|...|....:.|...:.|:.|:. ||||...|..
Zfish   398 TARNAIGETV-QPVSLEVRYAPKILGSV-AVYTWEGNPANISCEVLAHPSDVSITWLRDGFQLPN 460

  Fly   274 GSYESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMGQTDRIITVHHKAKKHGQHSHQTSSR 338
            .:..::.: |.......:.:.|.::.|||.|.|...|.:|                     |.||
Zfish   461 ANTSNIKI-HNTPSASYLEVNPESQSDFGNYNCTTSNEIG---------------------TESR 503

  Fly   339 ESQFIVI 345
            |  ||:|
Zfish   504 E--FIMI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	18/85 (21%)
		Ig	39..122	CDD:299845	17/82 (21%)
		Ig	132..213	CDD:299845	33/103 (32%)
		IG_like	141..227	CDD:214653	34/106 (32%)
		IG_like	239..322	CDD:214653	19/83 (23%)
		IGc2	245..313	CDD:197706	17/68 (25%)
ncam1b	XP_005157462.1	Ig	20..112	CDD:299845
		I-set	21..111	CDD:254352
		IG_like	121..205	CDD:214653
		IGc2	128..189	CDD:197706
		Ig	208..301	CDD:299845	20/93 (22%)
		I-set	212..298	CDD:254352	19/90 (21%)
		I-set	298..414	CDD:254352	40/120 (33%)
		Ig	300..414	CDD:299845	39/118 (33%)
		IG_like	426..505	CDD:214653	23/102 (23%)
		Ig	434..505	CDD:143165	21/94 (22%)
		FN3	513..606	CDD:238020
		FN3	629..720	CDD:238020
		Chorion_3	<815..1019	CDD:253174
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910