DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and STE13

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_014862.3	Gene:	STE13 / 854394	SGDID:	S000005745	Length:	931	Species:	Saccharomyces cerevisiae

Alignment Length:	1004	Identity:	226/1004 - (22%)
Similarity:	393/1004 - (39%)	Gaps:	251/1004 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EQDNYDDELVSSNPNQRNWRG-------------ILIALLVIIIVLALIVTSVV--LLTPP--DE 50
            |..::.....|.|...|.|..             .||||.|:::::.||.:.::  .:|.|  ..
Yeast    91 ENQHHTHSFFSVNKFNRRWGEWSLPEKRSYVLVFTLIALSVLVLLVILIPSKLLPTKITRPKTSA 155

  Fly    51 GPRVKGQR-IKLQDIVDGLFV-----------PQHSNG-----------SWIDGE-EFL------ 85
            |....|:| ..::::::|.|.           ||...|           ..|||. .|:
Yeast   156 GDSSLGKRSFSIENVLNGDFAIPEDTFHFIDPPQRLLGQDSDPGLYFTTKEIDGHTNFIAKQLFD 220

  Fly    86 --YQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYT 148
              ::.:||          ..|.|...|.| |:|........||  |:...|:...||||....|.
Yeast   221 ETFEVNLG----------GNRFLYEGVEF-TVSTVQINYKLDK--LIFGTNLESEFRHSSKGFYW 272

  Fly   149 LYDIQTSESIKLRHSPHQDEWPY------LHYARFTPAGNALVWVQSYDIYYREEVRSASVHRIT 207
            :.|:.|. :|:....|.:.:..|      |.||.|:||.|.:.:|...:::. ::|.|....::|
Yeast   273 IKDLNTG-NIEPILPPEKSDDNYELGLSKLSYAHFSPAYNYIYFVYENNLFL-QQVNSGVAKKVT 335

  Fly   208 HDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGA 272
            .|.... ::|..|||:||||:|.::.|||.:.:....::|.||||.|.:.....|.....:
Yeast   336 EDGSKD-IFNAKPDWIYEEEVLASDQAIWWAPDDSKAVFARFNDTSVDDIRLNRYTNMNEA---- 395

  Fly   273 AAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLH 337
                                       |.....::|||||.|||...|.:.:|::.:      ::
Yeast   396 ---------------------------YLSDTKIKYPKPGFQNPQFDLFLVNLQNGI------IY 427

  Fly   338 PPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGD-GRGWV--- 398
            .......:|....:..|:|.........:|...|..|.|...|..|.:.....:.: ..||:
Yeast   428 SINTGGQKDSILYNGKWISPDTFRFEITDRNSKILDVKVYDIPSSQMLTVRNTNSNLFNGWIEKT 492

  Fly   399 -DTVAVPLFAANASIYVAISP---LRDGLFGY---------FRHIVHV-DIDKNRVLPLTHGPYE 449
             |.:::|             |   |:...:||         |.|:.:. .:.....:.||.|.:|
Yeast   493 KDILSIP-------------PKPELKRMDYGYIDIHADSRGFSHLFYYPTVFAKEPIQLTKGNWE 544

  Fly   450 V--NRLLHWDQLDNWIYFLGTPERLPSQQHLYRVS---ALPARQGQALRSPDCLTCPAVSQWSEG 509
            |  |.::.::...:.|:|......:.| ||||.:|   :......|:|::|           |:.
Yeast   545 VTGNGIVGYEYETDTIFFTANEIGVMS-QHLYSISLTDSTTQNTFQSLQNP-----------SDK 597

  Fly   510 YDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFP 574
            ||                                                        :::  |.
Yeast   598 YD--------------------------------------------------------FYD--FE 604

  Fly   575 ISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLEL 639
            :|..|:|.:...|||..|..:. |..:...:.|:....|..|
Yeast   605 LSSSARYAISKKLGPDTPIKVA-GPLTRVLNVAEIHDDSILQ----------------------- 645

  Fly   640 LVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGS 704
               :..:.:.|||:....:|......:::..|.........|..|...:  :||.::::|.||||
Yeast   646 ---LTKDEKFKEKIKNYDLPITSYKTMVLDDGVEINYIEIKPANLNPKK--KYPILVNIYGGPGS 705

  Fly   705 QLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVS-EYLRDN 768
            |..|....:.:...:....|.||::|:.||:.|:|:.......::||..|..|..||: ::::.|
Yeast   706 QTFTTKSSLAFEQAVVSGLDVIVLQIEPRGTGGKGWSFRSWAREKLGYWEPRDITEVTKKFIQRN 770

  Fly   769 LHFIDSRRMGVWGWSYGGYTAALAL-AGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDN 832
            ...||..::.:|||||||:|:...: ......|:..::|:|||||.||||.|.|||::.|  ::|
Yeast   771 SQHIDESKIAIWGWSYGGFTSLKTVELDNGDTFKYAMAVAPVTNWTLYDSVYTERYMNQP--SEN 833

  Fly   833 YKGY-EESDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVL-YKQQIYPDEGHSL 895
            ::|| |.|.:..:......::..:||||.|||||:|.:..|...|...|:. |...|:||..||:
Yeast   834 HEGYFEVSTIQNFKSFESLKRLFIVHGTFDDNVHIQNTFRLVDQLNLLGLTNYDMHIFPDSDHSI 898

  Fly   896 --SGVKRHLYRSMTAFFEDCFKKLIDQQQ 922
              ...:|.:::.:..:..|.|.:..|..:
Yeast   899 RYHNAQRIVFQKLYYWLRDAFAERFDNTE 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	92/409 (22%)
		DAP2	<641..916	CDD:224423	84/280 (30%)
		Peptidase_S9	711..916	CDD:278741	68/210 (32%)
STE13	NP_014862.3	DPPIV_N	247..623	CDD:395744	102/500 (20%)
STE13	NP_014862.3	DAP2	359..922	CDD:224423	156/713 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
TreeFam	0	0.000	Not matched by this tool.
	8	7.960