DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11319 and dpp6b

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001108594.1	Gene:	dpp6b / 566832	ZFINID:	ZDB-GENE-070705-88	Length:	868	Species:	Danio rerio

Alignment Length:	943	Identity:	283/943 - (30%)
Similarity:	451/943 - (47%)	Gaps:	169/943 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EQDNYDDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDG 67
            :.|| :.|||..:..||||:||.||||||:::.:||||||:||||.::......|::.::||..|
Zfish    76 DADN-EGELVGGSAPQRNWKGIAIALLVILVICSLIVTSVILLTPVEDTSLASKQKVTIEDIFSG 139

  Fly    68 LFVPQHSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLA 132
            .....:...:|:...|.||.||.|.:.:||......:.|:.|.||:|..|..:.:|.|.:|:|||
Zfish   140 KLQAHNPQATWLSDTELLYHDHDGNVKMLNIQTNYNKTLVENKTFETYRPTQYQVSPDLKYVLLA 204

  Fly   133 QNVVKLFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREE 197
            .|::.::::|::|.|.:..:.:.|.::|  :|::.:...|.||.:.|.|..|:::...:|||:.:
Zfish   205 YNIMPIYQYSFMAYYIICSLDSPERVEL--TPNEVQSTALQYAGWGPKGQQLIFIFENNIYYKAQ 267

  Fly   198 VRSASVHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWY 262
            |.|.|:..::..:: ||::||:.||||||||...:.|.|.|.:|..:.|||.|||.|.:.....:
Zfish   268 VNSPSIRLVSTGSL-GVIFNGLADWLYEEEIFQNHIAHWWSPDGLRLAYATINDTLVPKMEIPMF 331

  Fly   263 GTTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKD 327
            .:.                                 |||..:..||||.|.:||.:.|.|..|..
Zfish   332 TSV---------------------------------LYPNGQEYRYPKAGEENPEIYLSVVSLNG 363

  Fly   328 PL-KVHITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVS 391
            || .|.:.....|:|  .:|:|.:...|.:.:|:||.||||.||.|::::|:|....|.:.|...
Zfish   364 PLHTVRMKKPEDPRI--RKDYYITMVKWATSTKLAVNWLNRAQNSSILTLCEATTGICTKKHEDE 426

  Fly   392 GDGRGWVDTV-AVPLFAANASIYVAISPLRDGLFGYFRHIVHVDIDKN----RVLPLTHGPYEVN 451
            .|  .|:... ..|||:.:...:.....:..|..|.|.||.......|    .:..||.|.::|.
Zfish   427 SD--SWLHRQNEPPLFSKDGYRFFFTRAVPQGGRGKFFHISMSTSQPNSSTDTLQSLTSGDWDVT 489

  Fly   452 RLLHWDQLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTK 516
            ::|.:::....:|||.| |...|::.||..:.    .|...|.  ||:|    .:..||..|
Zfish   490 QILAYNEDTRIVYFLST-EDGASRRQLYSANT----TGSFNRR--CLSC----NFRCGYVSG--- 540

  Fly   517 SPPKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKY 581
                                                                     ..|..|.|
Zfish   541 ---------------------------------------------------------SFSPDANY 548

  Fly   582 VLIDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNN 646
            ..::|.||.||.|.:|               ||:..:                  .|.::.|:.|
Zfish   549 FFLNCKGPGVPHSAVY---------------STRYGQ------------------YEKILDVETN 580

  Fly   647 TRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHW 711
            ..|...:..|.||.::...|.|. .|...:::..|.|.  ...:.||.:|.|...||.|:||:.:
Zfish   581 ELLNVTVNNTQMPIVEYRNVNID-DYVLSMQILKPAVF--VATSHYPLLLLVDGTPGGQMVTEQF 642

  Fly   712 HVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRR 776
            .|||:|.|..|.:.|||.:|||||..||..|||.|.|:||..|..|.||... :...:.:||:.|
Zfish   643 QVDWSTVLVSSFNTIVVRLDGRGSGFQGTNLLHRVKKKLGEFEERDHLEALR-IMSQMTYIDNSR 706

  Fly   777 MGVWGWSYGGYTAALALAGQQS------IFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKG 835
            :||:|.:||||.|:..|...:|      ..:||.:|||:|::.:|.|.::||||..|.:  |.:.
Zfish   707 IGVYGKAYGGYLASRLLHLDESPNLSKIKIKCGTAVSPITDFSIYASAFSERYLGLPQI--NKRE 769

  Fly   836 YEESDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSG--V 898
            ||.:.|:..::.|||::.:::|.|||:.||.|.:......|.::...|..||||||||.|:.  .
Zfish   770 YEMARLTDRMEQLRDKKLMIIHPTADEKVHFQHTAKFINHLINEKANYTLQIYPDEGHFLNSKDS 834

  Fly   899 KRHLYRSMTAFFEDCF--KKLI--DQQQQNQTD 927
            ::||.:|:..||.:||  .::|  :::|.|:.|
Zfish   835 QQHLSQSLVNFFVECFTPPEIIQSEEKQDNEDD 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	112/386 (29%)
		DAP2	<641..916	CDD:224423	105/284 (37%)
		Peptidase_S9	711..916	CDD:278741	85/214 (40%)
dpp6b	NP_001108594.1	DPPIV_N	195..560	CDD:279298	122/475 (26%)
		DAP2	<433..850	CDD:224423	146/526 (28%)
		Abhydrolase	642..850	CDD:304388	83/210 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3415
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1679
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830