Protein Alignment Dpp10 and APEH

DIOPT Version :10

• Sequence 1: NP_001285682.1
• Gene: Dpp10 / 33923
• FlyBaseID: FBgn0031835
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_011531960.1
• Gene: APEH / 327
• HGNCID: 586
• Length: 777
• Species: Homo sapiens
• Alignment Length: 821
• Identity: 155/821 - (18%)
• Similarity: 275/821 - (33%)
• Gaps: 230/821 - (28%)

  Fly   241 GQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPG-----AGGSNPHASLY 300
            |:..|.|...|:..|.:|.|  |:.||..|..|.......  ..:.:||     |..|.|.::..
Human     6 GKGKLQARQVDSQSQARHGA--GSQGPECGRPARLRPFYP--PRSRAPGFRFHRAAPSPPRSNAS 66

  Fly   301 P--EIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHY----------FSSAS 353
            |  .:.|...|.|..::..::.|.              .|.||.|.:...          .:|..
Human    67 PLGRVLSPSRPAPCQRSSPISRRP--------------RPSQIAAGQGRRQPGPSQAPPPEASLP 117

  Fly   354 WVSHSKIAVVWLNRPQNISVVS------VCKAPLFQCIETHRVSGDGRG--------WVDTVAVP 404
            ..|..::|.....|..|:.::|      ..||.|      .:..|.|.|        |.....:.
Human   118 GASTPRLAPAAERRLWNVRLLSRESPSGTMKAVL------RKAGGTGPGEEKQFLEVWEKNRKLK 176

  Fly   405 LFAANASIYVAISPL-RDGLFGYF------RHIVHVDIDK---------NRVLPLTHGPYEVNRL 453
            .|  |.|......|: .|..||..      .|:::|...|         .:.|.::....|:.||
Human   177 SF--NLSALEKHGPVYEDDCFGCLSWSHSETHLLYVAEKKRPKAESFFQTKALDVSASDDEIARL 239

  Fly   454 LHWDQL---DNWIYFLGTPERLPSQQ------------HLYRVSALP--ARQGQALRSPDCLTCP 501
            ...||.   |.::::....|.:.|:.            ::..:..:|  ...|||..:|......
Human   240 KKPDQAIKGDQFVFYEDWGENMVSKSIPVLCVLDVESGNISVLEGVPENVSPGQAFWAPGDAGVV 304

  Fly   502 AVSQWSEGY----------------------------DEGHTKSPPKLVTAWDDDWEDSEEAEAQ 538
            .|..|.|.:                            |:....|.|:|                .
Human   305 FVGWWHEPFRLGIRFCTNRRSALYYVDLIGGKCELLSDDSLAVSSPRL----------------S 353

  Fly   539 PPQPALPVEQQPP--GRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSI------ 595
            |.|..:...|.|.  ...|.:.|      |||     ....:...|::|    |||..:
Human   354 PDQCRIVYLQYPSLIPHHQCSQL------CLY-----DWYTKVTSVVVD----VVPRQLGENFSG 403

  Fly   596 ----LYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEP------KSQFLELLVIVQNNTRLK 650
                |..|...:|||.:....|.|:........|.:.|...      .....:||.|.|:  .:.
Human   404 IYCSLLPLGCWSADSQRVVFDSAQRSRQDLFAVDTQVGTVTSLTAGGSGGSWKLLTIDQD--LMV 466

  Fly   651 EKMAKTAMPQIKTFPVMISGG------------------YHAQVRLYLPPVLRED---------- 687
            .:.:..::|.......:.|.|                  .|..:|:..||..:|:
Human   467 AQFSTPSLPPTLKVGFLPSAGKEQSVLWVSLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEA 531

  Fly   688 ---------EITRYPTILHVYSGPGSQLVTDHWHVDWNTY--LSGSKDYIVVEIDGRGSAGQGYQ 741
                     :.|:.|.::..:.||.|..||     .|..:  :.....:.|:.::.|||.|.|..
Human   532 ILLQPGSPPDKTQVPMVVMPHGGPHSSFVT-----AWMLFPAMLCKMGFAVLLVNYRGSTGFGQD 591

  Fly   742 LLHEVYKRLGSVEVSD-QLEVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQCGIS 805
            .:..:...:|..:|.| |..|.:.|::. || |:..:.:.|.|:||:.:...:......::..::
Human   592 SILSLPGNVGHQDVKDVQFAVEQVLQEE-HF-DASHVALMGGSHGGFISCHLIGQYPETYRACVA 654

  Fly   806 VSPVTN------------WKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQFLLVHG 858
            .:||.|            |.:.::.:.......|:::...:..::|.: :|:..:: ...||:.|
Human   655 RNPVINIASMLGSTDIPDWCVVEAGFPFSSDCLPDLSVWAEMLDKSPI-RYIPQVK-TPLLLMLG 717

  Fly   859 TADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGVK 899
            ..|..|..:|.|...|:|.::.|..:..:||...|:||.|:
Human   718 QEDRRVPFKQGMEYYRALKTRNVPVRLLLYPKSTHALSEVE 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dpp10	NP_001285682.1	DPPIV_N	123..504	CDD:395744	63/326 (19%)
		Peptidase_S9	711..916	CDD:459761	43/204 (21%)
APEH	XP_011531960.1	PHA03378	<24..>128	CDD:223065	23/121 (19%)
		APEH_N	<142..330	CDD:466026	34/195 (17%)
		TolB	322..>455	CDD:440585	27/163 (17%)
		DAP2	526..776	CDD:441115	50/242 (21%)