DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and Dpp6

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_038963130.1	Gene:	Dpp6 / 29272	RGDID:	68402	Length:	867	Species:	Rattus norvegicus

Alignment Length:	924	Identity:	279/924 - (30%)
Similarity:	430/924 - (46%)	Gaps:	163/924 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QDNYDDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGL 68
            ||...:|||.|||.||||:||.||||||:::.:||||||:||||.::....:.:::.::|:....
  Rat    78 QDTPLEELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPAEDTSLSQKKKVTVEDLFSED 142

  Fly    69 FVPQHSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQ 133
            |........||..:||:|::..|.:.|.|....:..||:.....::|....:.||.||.|.|.:.
  Rat   143 FKIHDPEAKWISDKEFIYRERKGSVILRNVETNNSTVLIEGKKIESLRAIRYEISPDKEYALFSY 207

  Fly   134 NVVKLFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEV 198
            ||..:::||:...|.|..|...:...|  .|.:.....|.||.:.|.|..|:::...:|||...|
  Rat   208 NVEPVYQHSHTGYYVLSKIPHGDPQSL--DPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHV 270

  Fly   199 RSASVHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYG 263
            ...:: |:......||:|||:.|||||||||.::.|.|.|.:|..:.|||.||:.|.......|
  Rat   271 GKQAI-RVVSTGKEGVIYNGLSDWLYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLMELPTY- 333

  Fly   264 TTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDP 328
                                 ||           |:||.::...|||.|::||:::|.|..|..|
  Rat   334 ---------------------TG-----------SVYPTVKPYHYPKAGSENPSISLHVIGLNGP 366

  Fly   329 LKVHITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGD 393
              .|..::.||......::|.:...|.:.:|:||.||||.||:|::::|.|....|.:.|  ..:
  Rat   367 --THDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKH--EDE 427

  Fly   394 GRGWVDTV-AVPLFAANASIYVAISPLRDGLFGYFRHIV----HVDIDKNRVLPLTHGPYEVNRL 453
            ...|:... ..|:|:.:...:..:..:..|..|.|.||.    ..:...:.:..:|.|.::|..:
  Rat   428 SEAWLHRQNEEPVFSKDGRKFFFVRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTEI 492

  Fly   454 LHWDQLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSP 518
            |.:|:..|.:|||.| |.||.::|||..:.:.....|      ||:|..|
  Rat   493 LTYDEKRNKLYFLST-EDLPRRRHLYSANTVDDFNRQ------CLSCDLV--------------- 535

  Fly   519 PKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVL 583
                                                         .:|.|..|.|  |....:.|
  Rat   536 ---------------------------------------------ENCTYVSASF--SHNMDFFL 553

  Fly   584 IDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTR 648
            :.|.||.|||..:               |:|..                |.:..:|    :.|.:
  Rat   554 LKCEGPGVPTVTV---------------HNTTD----------------KRRMFDL----EANEQ 583

  Fly   649 LKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHV 713
            :::.:....||:|:...:.:. .|...:::..|...  .:...||.:|.|...||||.|::.:.|
  Rat   584 VQKAINDRQMPKIEYRKIEVE-DYSLPMQILKPATF--TDTAHYPLLLVVDGTPGSQSVSERFEV 645

  Fly   714 DWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLE-VSEYLRDNLHFIDSRRM 777
            .|.|.|..|...:||:.|||||..||.:|||||.:|||.:|..||:| |...|::  .:||..|:
  Rat   646 TWETVLVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGFLEEKDQMEAVRTMLKE--QYIDKTRV 708

  Fly   778 GVWGWSYGGYTAALAL----AGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEE 838
            .|:|..||||.:...|    ..|...|.||.::||:|::|||.|.::||||....: || :.||.
  Rat   709 AVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGL-DN-RAYEM 771

  Fly   839 SDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGV--KRH 901
            :.|:..|..|.|:|||::|.|||:.:|.|.:..|...|......|..||||||.|....|  |:|
  Rat   772 TKLAHRVSALEDQQFLIIHATADEKIHFQHTAELITQLIKGKANYSLQIYPDESHYFHSVALKQH 836

  Fly   902 LYRSMTAFFEDCFK 915
            ||||:..||.:||:
  Rat   837 LYRSIIGFFVECFR 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	112/385 (29%)
		DAP2	<641..916	CDD:224423	106/282 (38%)
		Peptidase_S9	711..916	CDD:278741	91/212 (43%)
Dpp6	XP_038963130.1	DPPIV_N	197..563	CDD:395744	123/474 (26%)
Dpp6	XP_038963130.1	Abhydrolase	643..852	CDD:419691	91/212 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7595
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1489
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830