DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and Dpp10

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_950186.3	Gene:	Dpp10 / 269109	MGIID:	2442409	Length:	800	Species:	Mus musculus

Alignment Length:	915	Identity:	284/915 - (31%)
Similarity:	450/915 - (49%)	Gaps:	156/915 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQ 72
            |.||.|::|.||||:||.||||||::|.:||..||:||| |||.......|:.|::::...|...
Mouse    23 DQELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLT-PDELTNSSETRLSLEELLGKGFGLH 86

  Fly    73 HSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVK 137
            :....||:....:|:.:.|.:..||..:.:..:|:.|.||.|......::|.|.:|:|||.:|.:
Mouse    87 NPEPRWINDTVVVYKTNNGHVMKLNTESNASTLLLDNSTFVTFKASRHSLSPDLKYVLLAYDVKQ 151

  Fly   138 LFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSAS 202
            :|.:|:.|.|.:|:|.|.|..:|  :|.:.|...|.||.:...|..|:::...:|||:.:::|:|
Mouse   152 IFHYSFTASYLIYNIHTGEVWEL--NPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSS 214

  Fly   203 VHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGP 267
            : |:|.....|:::|||.|||||||:||::.|.|.|.:|:.:.:...||:.|.....       |
Mouse   215 L-RLTSSGKEGIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPNMII-------P 271

  Fly   268 SAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVH 332
            ...||                          |||:.:...|||.|..||:|.|.|.:|..|  .|
Mouse   272 RFTGA--------------------------LYPKAKQYPYPKAGQANPSVKLYVVNLYGP--TH 308

  Fly   333 ITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGW 397
            ..:|.||.|..:.::|.:...|||:::..|.|||||||||::::|::....|...:.::.|  .|
Mouse   309 TLELMPPDIFKSREYYITMVKWVSNTRTVVRWLNRPQNISILTLCESTTGACSRKYEMTSD--TW 371

  Fly   398 VDTV-AVPLFAANASIYVAISPLRDGLFGYFRHI----VHVDIDKNRVLPLTHGPYEVNRLLHWD 457
            :... ..|:|:.:.|.:....|::.|..|.|.||    |....::..|..||.|.:||.|:|.:|
Mouse   372 LSKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVIRILAYD 436

  Fly   458 QLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLV 522
            :....||||.| |..|..:.||..|.      :.|.:.||::|..:.:
Mouse   437 ETTQKIYFLST-ESSPQGRQLYSAST------EGLLNRDCISCNFMKE----------------- 477

  Fly   523 TAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCL 587
                                                      ||.|.:|.|  |...::.|:.|.
Mouse   478 ------------------------------------------DCTYFDASF--SPMNQHFLLFCE 498

  Fly   588 GPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEK 652
            ||.||...|               |.|               :.|...||     ::||:.:||.
Mouse   499 GPKVPVVSL---------------HIT---------------DNPSRYFL-----LENNSVMKET 528

  Fly   653 MAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNT 717
            :.|..:.:.:| .::....|...::|..|....|.  .:|..:|.:...||.|:|||.:||||::
Mouse   529 IQKKKLAKRET-RILHIDDYELPLQLSFPKDFMEK--NQYALLLIMDEEPGGQMVTDKFHVDWDS 590

  Fly   718 YLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRRMGVWGW 782
            .|..:.:.||...|||||..||.::|.|:::|:||||..||:...:||... .:|||:|:.::|.
Mouse   591 VLIDTDNVIVARFDGRGSGFQGLKVLQEIHRRIGSVEAKDQVAAVKYLLKQ-PYIDSKRLSIFGK 654

  Fly   783 SYGGYTAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDN 847
            .||||.|::.|...:..|:||..|:|:::.|||.|.::||||..|:..::  .|:.|.:...:..
Mouse   655 GYGGYIASMILKSDEKFFKCGAVVAPISDMKLYASAFSERYLGMPSKEES--TYQASSVLHNIHG 717

  Fly   848 LRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSG-VKRHLYRSMTAFFE 911
            |::...|::|||||..||.|.|..|.:.|...||.|..|:|||||:.:|. .|.|.|.::..||.
Mouse   718 LKEENLLIIHGTADTKVHFQHSAELIKHLIKAGVNYTLQVYPDEGYHISDKSKHHFYSTILRFFS 782

  Fly   912 DCFKK 916
            ||.|:
Mouse   783 DCLKE 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	123/385 (32%)
		DAP2	<641..916	CDD:224423	100/275 (36%)
		Peptidase_S9	711..916	CDD:278741	82/205 (40%)
Dpp10	NP_950186.3	DPPIV_N	137..503	CDD:279298	133/473 (28%)
Dpp10	NP_950186.3	Peptidase_S9	584..786	CDD:278741	82/204 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3179
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41400
Inparanoid	1	1.050	464	1.000	Inparanoid score	I1533
Isobase	1	0.950	-	0	Normalized mean entropy	S2644
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.770