Protein Alignment Dpp10 and FAP

DIOPT Version :10

• Sequence 1: NP_001285682.1
• Gene: Dpp10 / 33923
• FlyBaseID: FBgn0031835
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_004451.2
• Gene: FAP / 2191
• HGNCID: 3590
• Length: 760
• Species: Homo sapiens
• Alignment Length: 894
• Identity: 261/894 - (29%)
• Similarity: 420/894 - (46%)
• Gaps: 166/894 - (18%)

  Fly    34 VLALIVTSVVLLTPPDEGPRVKGQR-IKLQDIVDGLFVPQHSNGSWIDGEEFLYQDHLGRICLLN 97
            ||||:|..:||.............| :.|:||::|.|..:....:||.|:|:|:|.....|.|.|
Human    16 VLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYN 80

  Fly    98 AANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQTSESIKLRH 162
            ........::||.|.|:::...:.:|.|::::.|..:..||:|:||.|.|.:||:...|.::...
Human    81 IETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNE 145

  Fly   163 SPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYEEE 227
            .|..     :.|..::|.|:.|.:|...:||.::...... .:||.:.....::||||||:||||
Human   146 LPRP-----IQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP-FQITFNGRENKIFNGIPDWVYEEE 204

  Fly   228 ILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGAGG 292
            :|....|:|.|.||:.:.||.||||.:....:::||.
Human   205 MLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGD---------------------------- 241

  Fly   293 SNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHYFSSASWVSH 357
                 ..||...::.|||.|.:||.|.:.:.|...|..|...::..|.:||:.|:|||..:||:.
Human   242 -----EQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTD 301

  Fly   358 SKIAVVWLNRPQNISVVSVCKA----PLFQCIETHRVSGDGR-GWVD--TVAVPLFAANASIYVA 415
            .::.:.||.|.||:||:|:|..    ..:.|.:|.....:.| ||..  .|:.|:|:.:|..|..
Human   302 ERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYK 366

  Fly   416 ISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWIYFLGTPERLPSQQHLYR 480
            |...:||    ::||.::.......:.:|.|.:|...:....| |:..|.....|..|.::::||
Human   367 IFSDKDG----YKHIHYIKDTVENAIQITSGKWEAINIFRVTQ-DSLFYSSNEFEEYPGRRNIYR 426

  Fly   481 VSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALP 545
            :|.     |....|..|:||             |.:.
Human   427 ISI-----GSYPPSKKCVTC-------------HLRK---------------------------- 445

  Fly   546 VEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAKTK 610
                              ..|.|:.|.|  |..|||..:.|.||.:|.|.|:
Human   446 ------------------ERCQYYTASF--SDYAKYYALVCYGPGIPISTLH------------- 477

  Fly   611 RHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMP--QIKTFPV-MISGGY 672
                          |.:..:|.|        |::.|..|:..:....:|  :||...| .|:..|
Human   478 --------------DGRTDQEIK--------ILEENKELENALKNIQLPKEEIKKLEVDEITLWY 520

  Fly   673 HAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAG 737
                ::.|||  :.|...:||.::.||.||.||.|...:.|:|.:||:..:..::..:||||:|.
Human   521 ----KMILPP--QFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAF 579

  Fly   738 QGYQLLHEVYKRLGSVEVSDQL-EVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQ 801
            ||.:||:.||::||..||.||: .|.:::  .:.|||.:|:.:||||||||.::||||....:|:
Human   580 QGDKLLYAVYRKLGVYEVEDQITAVRKFI--EMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFK 642

  Fly   802 CGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQFLLVHGTADDNVHV 866
            |||:|:||::|:.|.|.|.||::..|...||.:.|:.|.:....:..|:..:||:|||||||||.
Human   643 CGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHF 707

  Fly   867 QQSMVLARSLTSKGVLYKQQIYPDEGHSLSGVK-RHLYRSMTAFFEDCF 914
            |.|..:|::|.:..|.::...|.|:.|.|||:. .|||..||.|.:.||
Human   708 QNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCF 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dpp10	NP_001285682.1	DPPIV_N	123..504	CDD:395744	108/387 (28%)
		Peptidase_S9	711..916	CDD:459761	87/206 (42%)
FAP	NP_004451.2	DPPIV_N	106..473	CDD:395744	120/476 (25%)
		Peptidase_S9	553..756	CDD:459761	85/204 (42%)