Protein Alignment Dpp10 and Fap

DIOPT Version :10

• Sequence 1: NP_001285682.1
• Gene: Dpp10 / 33923
• FlyBaseID: FBgn0031835
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_620205.1
• Gene: Fap / 192203
• RGDID: 621253
• Length: 761
• Species: Rattus norvegicus
• Alignment Length: 894
• Identity: 253/894 - (28%)
• Similarity: 421/894 - (47%)
• Gaps: 161/894 - (18%)

  Fly    32 IIVLALIVTSVVLLTPPDEGPRVK-GQRIKLQDIVDGLFVPQHSNGSWIDGEEFLYQDHLGRICL 95
            ::.|||:|..:||.......|... |:.:.|:||::|.|..:....:||..:|:|:|.....|..
  Rat    14 LVALALVVICIVLRPSRVYSPEGNTGRSLTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVF 78

  Fly    96 LNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQTSESIKL 160
            .|...|...:::||.|.|:::...:.:|.|::::.|..:..||:|:||.|.|.:||:|..|.::.
  Rat    79 YNIETRESYIILSNSTMKSVNATDYGLSPDRQFIYLESDYSKLWRYSYTATYYIYDLQNGEFVRG 143

  Fly   161 RHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYE 225
            ...|..     :.|..::|.|:.|.:|...:||.::...... .:||:......::||||||:||
  Rat   144 YELPRP-----IQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP-FQITYTGRENRIFNGIPDWVYE 202

  Fly   226 EEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGA 290
            ||:|....|:|.|.:|:.:.|..|||:.:....:::||.
  Rat   203 EEMLATKYALWWSPDGKYLAYVEFNDSDIPIIAYSYYGD-------------------------- 241

  Fly   291 GGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHYFSSASWV 355
                   ..||...::.|||.|.:||.|.:.:.|...|..|...::..|::||:.|:||:..:||
  Rat   242 -------GQYPRTINIPYPKAGAKNPIVRVFIVDTIYPHHVGPIEVPVPEMIASSDYYFTWLTWV 299

  Fly   356 SHSKIAVVWLNRPQNISVVSVCKA----PLFQCIETHRVSGDGR-GWVD--TVAVPLFAANASIY 413
            ::.::.:.||.|.||:||:|:|..    ..:.|.:......:.| ||..  .|:.|.|:.:|:.|
  Rat   300 TNERVCLQWLKRVQNVSVLSICDFREDWHAWDCPKNQEHIEESRTGWAGGFFVSTPAFSQDAASY 364

  Fly   414 VAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWIYFLGTPERLPSQQHL 478
            ..|...:||    ::||.::.......:.:|.|.:|...:....| |:..|.....|..|.::::
  Rat   365 YKIFSDKDG----YKHIHYIKDTVENAIQITSGKWEAIYIFRVTQ-DSLFYSSNEFEGYPGRRNI 424

  Fly   479 YRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPA 543
            ||:|.     |.:..|..|:||             |.:.
  Rat   425 YRISI-----GNSPPSKKCVTC-------------HLRK-------------------------- 445

  Fly   544 LPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAK 608
                                ..|.|:.|.|  |.:|||..:.|.||.:|.|.|:..:
  Rat   446 --------------------ERCQYYTASF--SYKAKYYALICYGPGLPISTLHDGR-------- 480

  Fly   609 TKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYH 673
                 |.||                      :.:::.|..|:..:....:|.:: ...:..||..
  Rat   481 -----TDQE----------------------IQVLEENKELENALRNIQLPAVE-IKKLEDGGMT 517

  Fly   674 AQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQ 738
            ...::.|||  :.|...:||.::.||.||.||.|...:.|:|.|||:..:..:|..:||||:|.|
  Rat   518 FWYKMILPP--QFDRSKKYPLLIQVYGGPCSQSVKSVFSVNWITYLASKEGIVVALVDGRGTAFQ 580

  Fly   739 GYQLLHEVYKRLGSVEVSDQL-EVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQC 802
            |.:.||.||::||..||.||| .|.:::  .:.|||..|:.:||||||||.::||||....:|:|
  Rat   581 GDKFLHAVYRKLGVYEVEDQLTAVRKFI--EMGFIDEGRIAIWGWSYGGYVSSLALASGTGLFKC 643

  Fly   803 GISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQFLLVHGTADDNVHVQ 867
            ||:|:||::|:.|.|.|.||::..|...||.:.|:.|.:....:..|:..:||:|||||||||.|
  Rat   644 GIAVAPVSSWEYYASIYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQ 708

  Fly   868 QSMVLARSLTSKGVLYKQQIYPDEGHSLSG--VKRHLYRSMTAFFEDCF 914
            .|..:|::|.:..|.::...|.|:.|.:|.  .:.|||..||.|.:.||
  Rat   709 NSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCF 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dpp10	NP_001285682.1	DPPIV_N	123..504	CDD:395744	104/387 (27%)
		Peptidase_S9	711..916	CDD:459761	88/207 (43%)
Fap	NP_620205.1	DPPIV_N	106..473	CDD:395744	116/476 (24%)
		Peptidase_S9	553..757	CDD:459761	86/205 (42%)