DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and DPP6

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_570629.2	Gene:	DPP6 / 1804	HGNCID:	3010	Length:	865	Species:	Homo sapiens

Alignment Length:	920	Identity:	277/920 - (30%)
Similarity:	428/920 - (46%)	Gaps:	163/920 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQ 72
            :||||.|||.||||:||.||||||:::.:||||||:||||.::....:.:::.::|:....|...
Human    80 EDELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKIH 144

  Fly    73 HSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVK 137
            .....||...||:|::..|.:.|.|....:..||:.....::|....:.||.|:.|.|.:.||..
Human   145 DPEAKWISDTEFIYREQKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEP 209

  Fly   138 LFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSAS 202
            :::|||...|.|..|...:...|  .|.:.....|.||.:.|.|..|:::...:|||...|...:
Human   210 IYQHSYTGYYVLSKIPHGDPQSL--DPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQA 272

  Fly   203 VHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGP 267
            : |:......||:|||:.|||||||||..:.|.|.|.:|..:.||..||:.|.......|
Human   273 I-RVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTY----- 331

  Fly   268 SAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVH 332
                             ||           |:||.::...|||.|::||:::|.|..|..|  .|
Human   332 -----------------TG-----------SIYPTVKPYHYPKAGSENPSISLHVIGLNGP--TH 366

  Fly   333 ITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGW 397
            ..::.||......::|.:...|.:.:|:||.||||.||:|::::|.|....|.:.|  ..:...|
Human   367 DLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKH--EDESEAW 429

  Fly   398 VDTV-AVPLFAANASIYVAISPLRDGLFGYFRHIV----HVDIDKNRVLPLTHGPYEVNRLLHWD 457
            :... ..|:|:.:...:..|..:..|..|.|.||.    ..:...:.:..:|.|.::|.::|.:|
Human   430 LHRQNEEPVFSKDGRKFFFIRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYD 494

  Fly   458 QLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLV 522
            :..|.||||.| |.||.::.||..:.:    |...|  .||:|..|
Human   495 EKGNKIYFLST-EDLPRRRQLYSANTV----GNFNR--QCLSCDLV------------------- 533

  Fly   523 TAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCL 587
                                                     .:|.|..|.|  |....:.|:.|.
Human   534 -----------------------------------------ENCTYFSASF--SHSMDFFLLKCE 555

  Fly   588 GPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEK 652
            ||.||...:               |:|..                |.:..:|    :.|..:|:.
Human   556 GPGVPMVTV---------------HNTTD----------------KKKMFDL----ETNEHVKKA 585

  Fly   653 MAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNT 717
            :....||:::...:.|. .|:..:::..|...  .:.|.||.:|.|...||||.|.:.:.|.|.|
Human   586 INDRQMPKVEYRDIEID-DYNLPMQILKPATF--TDTTHYPLLLVVDGTPGSQSVAEKFEVSWET 647

  Fly   718 YLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLE-VSEYLRDNLHFIDSRRMGVWG 781
            .:..|...:||:.|||||..||.:|||||.:|||.:|..||:| |...|::  .:||..|:.|:|
Human   648 VMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRTMLKE--QYIDRTRVAVFG 710

  Fly   782 WSYGGYTAALAL----AGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLS 842
            ..||||.:...|    ..|...|.||.::||:|::|||.|.::||||....: || :.||.:.::
Human   711 KDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGL-DN-RAYEMTKVA 773

  Fly   843 KYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGH--SLSGVKRHLYRS 905
            ..|..|.::|||::|.|||:.:|.|.:..|...|......|..||||||.|  :.|.:|:|||||
Human   774 HRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRS 838

  Fly   906 MTAFFEDCFK 915
            :..||.:||:
Human   839 IINFFVECFR 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	113/385 (29%)
		DAP2	<641..916	CDD:224423	105/282 (37%)
		Peptidase_S9	711..916	CDD:278741	88/212 (42%)
DPP6	NP_570629.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		5/7 (71%)
		DPPIV_N	195..561	CDD:279298	124/474 (26%)
		Abhydrolase	641..850	CDD:304388	88/212 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3243
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1555
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830