Protein Alignment CG11319 and DPP4

DIOPT Version :9

• Sequence 1: NP_001285682.1
• Gene: CG11319 / 33923
• FlyBaseID: FBgn0031835
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001926.2
• Gene: DPP4 / 1803
• HGNCID: 3009
• Length: 766
• Species: Homo sapiens
• Alignment Length: 914
• Identity: 255/914 - (27%)
• Similarity: 412/914 - (45%)
• Gaps: 175/914 - (19%)

  Fly    21 WRGILIALLVIIIVLALIVTSVVLLTP-PDEGPRVKGQRIKLQDIVDGLFVPQHSNGSWIDGEEF 84
            |: :|:.||....::.:|...||||.. .|:......:...|.|.:...:..:..:..||...|:
Human     5 WK-VLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEY 68

  Fly    85 LYQDHLGRICLLNAANRSERVLMSNVTFKTL--SPFTFTISADKRYLLLAQNVVKLFRHSYLAQY 147
            ||:.. ..|.:.||...:..|.:.|.||...  |...::||.|.:::||..|.||.:||||.|.|
Human    69 LYKQE-NNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASY 132

  Fly   148 TLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVP 212
            .:||:...:.|.....|:..:|     ..::|.|:.|.:|.:.|||.:.|....| :|||.....
Human   133 DIYDLNKRQLITEERIPNNTQW-----VTWSPVGHKLAYVWNNDIYVKIEPNLPS-YRITWTGKE 191

  Fly   213 GVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAA 277
            .::||||.||:||||:..|.:|:|.|.||..:.||.||||.|....:::|
Human   192 DIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFY--------------- 241

  Fly   278 VGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTV------TLRVADLKDPLKVHITDL 336
                            :..:..||:...:.|||.|..||||      |..::.:.:...:.||
Human   242 ----------------SDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQIT-- 288

  Fly   337 HPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVC----KAPLFQC-IETHRVSGDGRG 396
             .|..:...|||....:|.:..:|::.||.|.||.||:.:|    .:..:.| :....:.....|
Human   289 -APASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTG 352

  Fly   397 WVDTV--AVPLFAANASIYVAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQL 459
            ||...  :.|.|..:.:.:..|....:|    :|||.:..|||.....:|.|.:||   :..:.|
Human   353 WVGRFRPSEPHFTLDGNSFYKIISNEEG----YRHICYFQIDKKDCTFITKGTWEV---IGIEAL 410

  Fly   460 -DNWIYFLGTPER-LPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLV 522
             .:::|::....: :|..::||::      |........||:|
Human   411 TSDYLYYISNEYKGMPGGRNLYKI------QLSDYTKVTCLSC---------------------- 447

  Fly   523 TAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCL 587
                         |..|.:                        |.|:...|  |::|||..:.|.
Human   448 -------------ELNPER------------------------CQYYSVSF--SKEAKYYQLRCS 473

  Fly   588 GPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEK 652
            ||.:|   ||.|.|:..|..                                |.::::|:.|.:.
Human   474 GPGLP---LYTLHSSVNDKG--------------------------------LRVLEDNSALDKM 503

  Fly   653 MAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNT 717
            :....||. |....:|........::.|||  ..|:..:||.:|.||:||.||.....:.::|.|
Human   504 LQNVQMPS-KKLDFIILNETKFWYQMILPP--HFDKSKKYPLLLDVYAGPCSQKADTVFRLNWAT 565

  Fly   718 YLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRRMGVWGW 782
            ||:.:::.||...|||||..||.:::|.:.:|||:.||.||:|.:... ..:.|:|::|:.:|||
Human   566 YLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQF-SKMGFVDNKRIAIWGW 629

  Fly   783 SYGGYTAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDN 847
            |||||..::.|.....:|:|||:|:||:.|:.|||.|.|||:..|...||...|..|.:....:|
Human   630 SYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAEN 694

  Fly   848 LRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSL--SGVKRHLYRSMTAFF 910
            .:..::||:|||||||||.|||..::::|...||.::...|.||.|.:  |...:|:|..|:.|.
Human   695 FKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFI 759

  Fly   911 EDCF 914
            :.||
Human   760 KQCF 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	108/395 (27%)
		DAP2	<641..916	CDD:224423	102/276 (37%)
		Peptidase_S9	711..916	CDD:278741	83/206 (40%)
DPP4	NP_001926.2	DPPIV_N	108..478	CDD:279298	120/483 (25%)
		DAP2	<398..764	CDD:224423	134/475 (28%)
		Peptidase_S9	559..763	CDD:278741	81/204 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3219
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720