DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and dpf-1

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_506850.1	Gene:	dpf-1 / 180042	WormBaseID:	WBGene00001054	Length:	799	Species:	Caenorhabditis elegans

Alignment Length:	972	Identity:	223/972 - (22%)
Similarity:	381/972 - (39%)	Gaps:	247/972 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DNYDDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDI----- 64
            :.||:||..:...:|:.:||..|::|::::|.:|..::|..||..........|:.:.|:
Worm     9 EGYDEELGGNESQKRDCKGITTAIVVVLLILVMIFAALVFFTPLFAAKSFGSWRLNVSDLRSLRY 73

  Fly    65 --VDGLFVPQHS--NGSWIDGEEFLYQDHLGRIC--------LLNAANRSERVLMSNVTFKTLSP 117
              .:..|...::  ..|| :|.| :.:|.:.|:.        :..:|:|....:|.:.....::|
Worm    74 PYAEFAFTDNNAVVMQSW-EGVE-IVEDGVSRLIFGRENGAEITPSADRKYFAMMDHAPNPGMNP 136

  Fly   118 ----FTFTISADKRYL--LLAQNVVKLFRHSYLAQYTLYDI--QTSESIKLRHSPHQDEWPYLHY 174
                |...|..:...|  ||...|.:|||....::.| |||  :..||:             :..
Worm   137 QNETFHLKIVNNNERLNPLLPFEVEELFRELSDSRIT-YDIGLRKEESV-------------IQA 187

  Fly   175 ARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSD 239
            .::....|..|:|:|..|||:.......:.|:::.....|  :|:.||:|||||....:|:|.|.
Worm   188 FKWNGKFNDFVFVESNKIYYQSSPEEEGLTRVSNGGEHTV--DGLFDWIYEEEIFGRKDAMWWST 250

  Fly   240 NGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIR 304
            .|..:.||::::...:......|....|                                ||...
Worm   251 KGDQLAYASYDNHLTKNVSLKTYHRLEP--------------------------------YPIDT 283

  Fly   305 SLRYPKPGTQ-NPTVTLRV------------ADLKDPLKVHITDLHPPQIIANEDHYFSSASWV- 355
            :..|||...: .||.||.:            ..|||.|..               ||..:..|:
Worm   284 NFHYPKTFAKVLPTYTLSIWNKKTEQSRQLDVQLKDSLSY---------------HYLLAVKWLE 333

  Fly   356 --SHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGWVDTVAVPLFAANASIYVAISP 418
              ...::..||.||.||...:::|......|..........:.||          ....:.:|:.
Worm   334 INGTEQLVSVWTNRYQNEVALTICDWDTAICRLEFEYKYASKRWV----------THDDFHSITS 388

  Fly   419 LRDGLFGYFRHIVHVDIDKN-------RVLPLTHGPYEVNRLLHWDQLD-----------NWIYF 465
            ..|.||....|      ||.       ..|.|:||.....:.|:..:.|           ..|:|
Worm   389 FEDTLFFLLPH------DKRDNAFQQVASLRLSHGQLRTPKFLNLGEYDVTSINGINKETRTIFF 447

  Fly   466 LGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWE 530
            .....: ||.:.|:..|.....:..|.    |::|..
Worm   448 HAAAPK-PSHRSLFSYSLADESRNSAY----CISCSI---------------------------- 479

  Fly   531 DSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSI 595
                                             .:|.:.:|:  :..|.|..::.|.||..|.:.
Worm   480 ---------------------------------KNCTWAQAQ--MDDQMKTAIVSCKGPAAPHTA 509

  Fly   596 LYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQ 660
            :..|  ...||.|...|:.                           ::.:.| .:.::.:..:|.
Worm   510 IVNL--TRMDSDKKTEHAN---------------------------LLYDKT-YQNRVEEAGLPV 544

  Fly   661 IKTFPVMISGGYHAQVRLYLP-PVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKD 724
            |....:.||..:.|.::|.:| .:...|:....|.|:|||.||..|...:...:.....::.:..
Worm   545 IIKETIKISDDFDALIKLSIPKDIYNRDKHQAIPLIVHVYGGPNDQNTKEATQIGIEEVVASASQ 609

  Fly   725 YIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLE-VSEYLRDNLHFIDSRRMGVWGWSYGGY- 787
            ..::.||||||.|:|::....:|.:||:|||.||:: :...||...|.:|:||:.|:||||||:
Worm   610 AAILRIDGRGSGGRGWKYRSAIYGQLGTVEVEDQIKAIKVVLRLYRHLLDARRVAVFGWSYGGFM 674

  Fly   788 TAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQ 852
            |.::.....:..|:|.:||:||||:..||:||.|||:....: ::|     ||::|.:||.:..:
Worm   675 TLSMVNEAPEQFFKCAVSVAPVTNFAYYDATYTERYMGDAPL-ESY-----SDVTKKLDNFKSTR 733

  Fly   853 FLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGVKRHLYRSMTAFFEDCF 914
            .||:||..|||||.|.|.:|...|.::||.:...:||::.||||....|:...||.|...||
Worm   734 LLLMHGLLDDNVHFQNSAILIDELQNRGVDFDLMVYPNQAHSLSSRTSHVVGKMTHFLRQCF 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	86/418 (21%)
		DAP2	<641..916	CDD:224423	95/277 (34%)
		Peptidase_S9	711..916	CDD:278741	78/206 (38%)
dpf-1	NP_506850.1	DPPIV_N	182..507	CDD:279298	82/470 (17%)
		DAP2	<524..798	CDD:224423	96/306 (31%)
		Peptidase_S9	615..795	CDD:278741	76/185 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I2534
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41400
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1947
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46052
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm8410
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980