DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and Fap

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_032012.1	Gene:	Fap / 14089	MGIID:	109608	Length:	761	Species:	Mus musculus

Alignment Length:	894	Identity:	254/894 - (28%)
Similarity:	422/894 - (47%)	Gaps:	161/894 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IIVLALIVTSVVLLTPPDEGPRVKGQR-IKLQDIVDGLFVPQHSNGSWIDGEEFLYQDHLGRICL 95
            :..|||:|..:||.......|....:| :.|:||::|.|..:....:||..:|:|:|.....|..
Mouse    14 LAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVF 78

  Fly    96 LNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQTSESIKL 160
            .|...|...:::||.|.|:::...:.:|.|::::.|..:..||:|:||.|.|.:||:|..|.::.
Mouse    79 YNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLQNGEFVRG 143

  Fly   161 RHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYE 225
            ...|..     :.|..::|.|:.|.:|...:||.::...... .:||:......::||||||:||
Mouse   144 YELPRP-----IQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP-FQITYTGRENRIFNGIPDWVYE 202

  Fly   226 EEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGA 290
            ||:|....|:|.|.:|:.:.|..|||:.:....:::||.
Mouse   203 EEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYGD-------------------------- 241

  Fly   291 GGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHYFSSASWV 355
                   ..||...::.|||.|.:||.|.:.:.|...|..|...::..|::||:.|:|||..:||
Mouse   242 -------GQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWV 299

  Fly   356 SHSKIAVVWLNRPQNISVVSVCKA----PLFQCIETHRVSGDGR-GWVD--TVAVPLFAANASIY 413
            |..::.:.||.|.||:||:|:|..    ..::|.:......:.| ||..  .|:.|.|:.:|:.|
Mouse   300 SSERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQDATSY 364

  Fly   414 VAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWIYFLGTPERLPSQQHL 478
            ..|...:||    ::||.::.......:.:|.|.:|...:....| |:..|.....|..|.::::
Mouse   365 YKIFSDKDG----YKHIHYIKDTVENAIQITSGKWEAIYIFRVTQ-DSLFYSSNEFEGYPGRRNI 424

  Fly   479 YRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPA 543
            ||:|.     |.:..|..|:||             |.:.
Mouse   425 YRISI-----GNSPPSKKCVTC-------------HLRK-------------------------- 445

  Fly   544 LPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAK 608
                                ..|.|:.|.|  |.:|||..:.|.||.:|.|.|:..:
Mouse   446 --------------------ERCQYYTASF--SYKAKYYALVCYGPGLPISTLHDGR-------- 480

  Fly   609 TKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYH 673
                 |.||                      :.:::.|..|:..:....:|::: ...:..||..
Mouse   481 -----TDQE----------------------IQVLEENKELENSLRNIQLPKVE-IKKLKDGGLT 517

  Fly   674 AQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQ 738
            ...::.|||  :.|...:||.::.||.||.||.|...:.|:|.|||:..:..::..:||||:|.|
Mouse   518 FWYKMILPP--QFDRSKKYPLLIQVYGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQ 580

  Fly   739 GYQLLHEVYKRLGSVEVSDQL-EVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQC 802
            |.:.||.||::||..||.||| .|.:::  .:.|||..|:.:||||||||.::||||....:|:|
Mouse   581 GDKFLHAVYRKLGVYEVEDQLTAVRKFI--EMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKC 643

  Fly   803 GISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQFLLVHGTADDNVHVQ 867
            ||:|:||::|:.|.|.|:||::..|...||.:.|:.|.:....:..|:..:||:|||||||||.|
Mouse   644 GIAVAPVSSWEYYASIYSERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQ 708

  Fly   868 QSMVLARSLTSKGVLYKQQIYPDEGHSLSG--VKRHLYRSMTAFFEDCF 914
            .|..:|::|.:..|.::...|.|:.|.:|.  .:.|||..||.|.:.||
Mouse   709 NSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCF 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	106/387 (27%)
		DAP2	<641..916	CDD:224423	105/277 (38%)
		Peptidase_S9	711..916	CDD:278741	87/207 (42%)
Fap	NP_032012.1	DPPIV_N	106..472	CDD:366374	118/475 (25%)
Fap	NP_032012.1	Peptidase_S9	553..757	CDD:366030	85/205 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3209
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720