DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and Dpp6

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_997165.2	Gene:	Dpp6 / 13483	MGIID:	94921	Length:	859	Species:	Mus musculus

Alignment Length:	920	Identity:	278/920 - (30%)
Similarity:	428/920 - (46%)	Gaps:	163/920 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQ 72
            :||||.|||.||||:||.||||||:::.:||||||:||||.::....:.:::.::|:....|...
Mouse    74 EDELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPAEDTSLSQKKKVTVEDLFSEDFKIH 138

  Fly    73 HSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVK 137
            .....||..:||:|::..|.:.|.|....:..||:.....::|....:.||.||.|:|.:.||..
Mouse   139 DPEAKWISNKEFIYRERKGSVILRNVETNNSTVLIEGKKIESLRAIRYEISPDKEYVLFSYNVEP 203

  Fly   138 LFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSAS 202
            :::||:...|.|..|...:...|  .|.:.....|.||.:.|.|..|:::...:|||...|...:
Mouse   204 VYQHSHTGYYVLSKIPHGDPQSL--DPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQA 266

  Fly   203 VHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGP 267
            : |:......||:|||:.|||||||||.::.|.|.|.:|..:.|||.||:.|.......|
Mouse   267 I-RVVSTGKEGVIYNGLSDWLYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLMELPTY----- 325

  Fly   268 SAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVH 332
                             ||           |:||.::...|||.|::||:::|.|..|..|  .|
Mouse   326 -----------------TG-----------SVYPTVKPYHYPKAGSENPSISLHVIGLNGP--TH 360

  Fly   333 ITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGW 397
            ..::.||......::|.:...|.:.:|:||.||||.||:|::::|.|....|.:.|  ..:...|
Mouse   361 DLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKH--EDESEAW 423

  Fly   398 VDTV-AVPLFAANASIYVAISPLRDGLFGYFRHIV----HVDIDKNRVLPLTHGPYEVNRLLHWD 457
            :... ..|:|:.:...:..:..:..|..|.|.||.    ..:...:.:..:|.|.::|.::|.:|
Mouse   424 LHRQNEEPVFSKDGRKFFFVRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILSYD 488

  Fly   458 QLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLV 522
            :..|.||||.| |.||.::|||..:.:.....|      ||:|..|
Mouse   489 EKRNKIYFLST-EDLPRRRHLYSANTVDDFNRQ------CLSCDLV------------------- 527

  Fly   523 TAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCL 587
                                                     .:|.|..|.|  |....:.|:.|.
Mouse   528 -----------------------------------------ENCTYVSASF--SHNMDFFLLKCE 549

  Fly   588 GPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEK 652
            ||.|||..:               |:|..                |.:..:|    :.|..:::.
Mouse   550 GPGVPTVTV---------------HNTTD----------------KRRMFDL----EANEEVQKA 579

  Fly   653 MAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNT 717
            :....||:|:...:.:. .|...:::..|...  .:...||.:|.|...||||.||:.:.|.|.|
Mouse   580 INDRQMPKIEYRKIEVE-DYSLPMQILKPATF--TDTAHYPLLLVVDGTPGSQSVTERFEVTWET 641

  Fly   718 YLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLE-VSEYLRDNLHFIDSRRMGVWG 781
            .|..|...:||:.|||||..||.:||.||.:|||.:|..||:| |...|::  .:||..|:.|:|
Mouse   642 VLVSSHGAVVVKCDGRGSGFQGTKLLQEVRRRLGFLEEKDQMEAVRTMLKE--QYIDKTRVAVFG 704

  Fly   782 WSYGGYTAALAL----AGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLS 842
            ..||||.:...|    ..|...|.||.::||:|::|||.|.::||||....: || :.||.:.|:
Mouse   705 KDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGL-DN-RAYEMTKLA 767

  Fly   843 KYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGV--KRHLYRS 905
            ..|..|.|:|||::|.|||:.:|.|.:..|...|......|..||||||.|....|  |:||.||
Mouse   768 HRVSALEDQQFLIIHATADEKIHFQHTAELITQLIKGKANYSLQIYPDESHYFHSVALKQHLSRS 832

  Fly   906 MTAFFEDCFK 915
            :..||.:||:
Mouse   833 IIGFFVECFR 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	113/385 (29%)
		DAP2	<641..916	CDD:224423	105/282 (37%)
		Peptidase_S9	711..916	CDD:278741	89/212 (42%)
Dpp6	NP_997165.2	DPPIV_N	189..555	CDD:279298	124/474 (26%)
Dpp6	NP_997165.2	Abhydrolase	639..841	CDD:304388	86/205 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7995
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	464	1.000	Inparanoid score	I1533
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830