DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11319 and apeh

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_942570.3	Gene:	apeh / 100333019	ZFINID:	ZDB-GENE-030131-9870	Length:	746	Species:	Danio rerio

Alignment Length:	809	Identity:	153/809 - (18%)
Similarity:	259/809 - (32%)	Gaps:	243/809 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 WVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYEE---EILHANNAIWMSDNGQLMLYA 247
            |.|. |:...|.|:....:.:.|.. ..|||:| |.....|   |:|..:     |.:|::....
Zfish    65 WTQR-DLERMENVKFCRQYIVFHHD-KSVVYSG-PSGNCTEIRGELLSVD-----SPSGEMKAVL 121

  Fly   248 TFNDTHVQEQHF--AWYG---------TTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYP 301
            ..|.|..:|:.|  .|:.         ||                           .|.|..:|.
Zfish   122 RENTTEGEEKQFLEIWHKNRKLKCLNLTT---------------------------LNKHGKVYE 159

  Fly   302 E-----------------IRSLRYPKPGT---QNPTVTLRVADLKDPLKVHITDLHPPQIIANED 346
            :                 |...:.||..:   |.|..:| ..|.::|:|   ||.....:..::.
Zfish   160 DDQFGCLVWSHSETHLLYIAEKKRPKTESYFQQGPETSL-TPDEEEPIK---TDKKEETVPGHQF 220

  Fly   347 HYFSSASW----VSHSKIAVVWLN-RPQNISVVSVCKAPLFQCIETHRVSGDGRGWVDTVAVPLF 406
            .|:.  .|    ||.|...:..|: ...||||:....|         .:|.....|..
Zfish   221 EYYE--DWGENLVSKSSPVLCVLDIEGSNISVLEGIPA---------AISPGQAFWAP------- 267

  Fly   407 AANASIYVA--ISPLRDGL--FGYFR-HIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWIYFL 466
            |....::|.  ..|.|.||  .|..| .:.:||:...:.                |||.:....:
Zfish   268 ADTGLLFVGWWHEPFRLGLKSCGNRRSSLFYVDLASGKC----------------DQLSSDSISV 316

  Fly   467 GTPERLPSQ-QHLYRVSALPARQGQALRSPDCL-------TCPAVSQWSEGYDEGHTKSPPKLVT 523
            .:|...|.. :.:|..|.:.....|..|.  |:       |...|.......|:|.|.....|::
Zfish   317 CSPRLSPDHCRIVYLESGVSCSHLQCHRL--CVFDWYTKQTSVVVDVVQRARDDGFTGIYSFLLS 379

  Fly   524 --AWDDDWEDSEEAEAQPPQPALPV------------EQQPPGRGQSAPLPPPPSDCLYHEAKFP 574
              .|..|.|......||..:..|.|            .|...|....
Zfish   380 PRCWSADSERVLFCSAQRSRKELFVVDTSSREITRLTSQSQEGSWNL------------------ 426

  Fly   575 ISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAK----TKRHSTQQEE----------PPTEGGD 625
            ::.....:::.|..|..|..:..|........:|    |...|..|.:          ||.:...
Zfish   427 LNIHRDLMVVSCSSPNSPPDLRVGFLPGKGSESKISWVTLEESQPQSDISWQTLNFSPPPEQDNT 491

  Fly   626 EKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEIT 690
            :.||.:     .:.|::...:|....|:....||
Zfish   492 QYPGLD-----FDALLLKPKDTPADGKLPLIVMP------------------------------- 520

  Fly   691 RYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEV 755
                    :.||.|.||:: |.:  :|.:.....:.|:.::.|||.|.|...:..:....|:.:|
Zfish   521 --------HGGPHSVLVSE-WIL--STAVLCKMGFSVLLVNYRGSLGFGQDNVFSLPGNCGTQDV 574

  Fly   756 SD-QLEVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQCGISVSPVTN-------- 811
            .| |..|...|:..  ..|.:::.|.|.|:||:.|...:......::..::.:||||
Zfish   575 KDVQFAVDSVLKQG--GFDEQKVAVIGGSHGGFLACHLIGQYPGFYKACVARNPVTNLASMVCCT 637

  Fly   812 ----WKLYDSTYAERYLSFPNVTDNYKGYEESDLS---KYVDNLRDRQFLLVHGTADDNVHVQQS 869
                |.:.::.:..:    |::.......|:..:.   |:|..:: ...||:.|..|..|..:|.
Zfish   638 DIPDWCIVEAGFDYK----PDIQLEPAILEQMLIKSPIKHVAKVK-TPVLLMLGEGDKRVPNKQG 697

  Fly   870 MVLARSLTSKGVLYKQQIYPDEGHSLSGV 898
            :...::|.|..|..:...||...||||.|
Zfish   698 IEYYKALKSLQVPVRVLWYPGNNHSLSKV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	71/369 (19%)
		DAP2	<641..916	CDD:224423	55/274 (20%)
		Peptidase_S9	711..916	CDD:278741	46/204 (23%)
apeh	NP_942570.3	DAP2	197..728	CDD:224423	122/642 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810