DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and dpp4

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001154809.1	Gene:	dpp4 / 100301982	ZFINID:	ZDB-GENE-081104-277	Length:	742	Species:	Danio rerio

Alignment Length:	908	Identity:	261/908 - (28%)
Similarity:	419/908 - (46%)	Gaps:	186/908 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQHSNGSWIDGEEFL 85
            |  :|.|..|::||:.:.|.:.:||......|:   :...|:|..:|....:..|..|:..:|:.
Zfish     6 W--LLAAFGVVVIVVLIAVPTAILLKEDKSEPQ---KTFTLEDYFNGTGRTKSYNMRWVSDDEYF 65

  Fly    86 YQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLY 150
            ::...|.:.|.||...:....::...|..::.|.:.:|||::|:....|..||:||:|.|.|::|
Zfish    66 HKTGEGSVFLFNATTGNGNEFVNQQIFARVAAFDYLVSADRKYVCFLSNYTKLWRHTYTASYSIY 130

  Fly   151 DIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVV 215
            |::..:.|. ...||.     :.|..::|.|:.|.:|..|::|.:|...|| ..::|.:....::
Zfish   131 DLEKRDFIN-TDIPHD-----VQYLAWSPTGHKLAFVWKYNVYVKETPNSA-FKQVTTNGAHNLI 188

  Fly   216 YNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGA 280
            .||:|||:||||:...|:|:|.|.||:.:.||.|||:.|....:.|:|
Zfish   189 LNGVPDWVYEEEMFSTNSALWWSPNGRFVAYAEFNDSEVHNIEYTWFG----------------- 236

  Fly   281 GGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANE 345
                            ...|||...:.|||.||.||||.|.|.|.....   |..:..|..:...
Zfish   237 ----------------EGQYPETVFVPYPKAGTPNPTVKLFVFDTNTNT---IKQVSVPSDVGAG 282

  Fly   346 DHYFSSASWVSHSKIAVVWLNRPQNISVVSV--------CKAPLFQCIETHRVSGDGRGWVDTVA 402
            :||.|:.:|.|..:|||.|..|.||..|:..        .:..|.|.|.:      ..|||...:
Zfish   283 EHYLSTVTWASDHRIAVQWQKRTQNYVVLETYDFNDGNWTEGSLSQIITS------STGWVGRFS 341

  Fly   403 --VPLFA--ANASIYVAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWI 463
              .|:|.  .|:..|:..:..|      |:|:.:. |...|:. ||.|.:||..:|  ...:|.:
Zfish   342 PDEPVFRPDGNSCYYILSNDER------FKHLAYF-IGTQRIF-LTRGKWEVISIL--KVTNNAL 396

  Fly   464 YFLGTP-ERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDD 527
            ||:... ...|.|:::|:::.    .|.:....:||||
Zfish   397 YFVSNEHNESPGQRNVYKITI----NGASHSDRECLTC--------------------------- 430

  Fly   528 DWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVP 592
                           .|..::                 |.|:.|.|  |.:..|.|:.|.||.:|
Zfish   431 ---------------TLNADR-----------------CKYNSATF--STEGSYYLMSCSGPGLP 461

  Fly   593 TSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTA 657
               ||.|:::.|:                                  |.:::||:.|:.|:.:.|
Zfish   462 ---LYTLRNSQAE----------------------------------LRVLENNSVLEHKLQEIA 489

  Fly   658 MPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGS 722
            ||. ..:..:..|.:....::.|||  |.|:..:||.::.||:||.||.....:.|.|:|||:.:
Zfish   490 MPS-NMYGKLKIGEFDLWYQMILPP--RFDKSKKYPLLIDVYAGPCSQKSDFRFRVGWSTYLAST 551

  Fly   723 KDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRRMGVWGWSYGGY 787
            :..||...|||||..||.|::|.:|||||:.||.||:..:....| :.|||..|:.:||||||||
Zfish   552 ERVIVASFDGRGSGYQGDQIMHALYKRLGTYEVEDQITAARQFID-MGFIDKSRIAIWGWSYGGY 615

  Fly   788 TAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQ 852
            ..::.|.....:|:||::|:||:.|:.|||.|.|||:..|  .:|...|:.|.::....:.:..|
Zfish   616 VTSMVLGAGSGVFKCGMAVAPVSKWEYYDSIYTERYMLTP--AENQAFYDNSTVTGRAKSFKSVQ 678

  Fly   853 FLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSG-VKRHLYRSMTAFFEDCF 914
            :||||||||||||.||:..::::|..:.|.:....|.||.|||.| ..:|:|..||.|.:.||
Zfish   679 YLLVHGTADDNVHFQQAAQISKALVDEQVDFDTMWYTDEDHSLGGSANQHVYTHMTHFLKTCF 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	113/393 (29%)
		DAP2	<641..916	CDD:224423	109/275 (40%)
		Peptidase_S9	711..916	CDD:278741	88/205 (43%)
dpp4	NP_001154809.1	DPPIV_N	103..461	CDD:279298	124/481 (26%)
		FrsA	509..733	CDD:223999	96/228 (42%)
		Peptidase_S9	540..741	CDD:278741	86/203 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2961
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.720