DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and fap

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001107145.1	Gene:	fap / 100134993	XenbaseID:	XB-GENE-482832	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	908	Identity:	260/908 - (28%)
Similarity:	415/908 - (45%)	Gaps:	178/908 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQHSNGSWIDGEEFLYQD 88
            ||..:|...||..|||| :||:|.......:|  .....|........|..:..||...|::.:.
Frog     7 ILFGVLAATIVTLLIVT-IVLVTSGFSNGDLK--TFSFDDAFSQNVSYQTYHHLWISENEYIRKT 68

  Fly    89 HLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQ 153
            ....:.:.|...|....::||.:|.:::...:.:|.|:|::||..|..|.:|:||.|.|.:|||:
Frog    69 SQNNLIIYNVETREASAILSNASFNSVNATNYILSYDRRFVLLESNYKKKWRYSYTASYHIYDIE 133

  Fly   154 TSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNG 218
            ....:|....|     |.:.|..:.|.|:.||:|...:||...|....:: .:|.|.....:|||
Frog   134 NGRFVKENELP-----PNIQYIHWAPKGHKLVYVLDNNIYLVYEPGQTAI-ALTSDGKENEIYNG 192

  Fly   219 IPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGA 283
            ||||:|||.:|..|.|.|.|.||:.:.|..|||..|....:::||
Frog   193 IPDWVYEELMLGGNYATWWSPNGKFIAYVQFNDKEVPVMEYSFYG-------------------- 237

  Fly   284 GTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHY 348
                         ...||....:.|||.|.:||||.|.:..:.||..:....:..|.::|:.|:|
Frog   238 -------------EDQYPRTMKISYPKAGAKNPTVKLFIVKVDDPDSIRTEQIQVPSLLASSDYY 289

  Fly   349 FSSASWVSHSKIAVVWLNRPQNISVVSVC----KAPLFQCIET-HRVSGDGRGWVDTV--AVPLF 406
            ||..:||...:::|.||.|.|||||:::|    ::..:.|.:: ..:.....||:...  .:|:|
Frog   290 FSWVTWVLDERVSVQWLPRSQNISVIAICDFKGRSNTWVCPKSQEHLEISETGWIGVFFPPLPVF 354

  Fly   407 AA-NASIYVAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQL------DNWIY 464
            .: |.|.|..:|...    || :||.::.....:.||:|||        :|:.:      :..||
Frog   355 TSDNLSYYQILSDQT----GY-KHIHYISDPGEKPLPITHG--------NWEAIYIYLVTNEAIY 406

  Fly   465 FLGTP-ERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDD 528
            :.... |..|.::|:||:..    ||.. |...|:||....:
Frog   407 YSSNEYEEAPGRRHIYRIGL----QGPQ-REKQCITCNVRRE----------------------- 443

  Fly   529 WEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPT 593
                                                .|.|:.|:|  |.:|||..:.|.||.:|.
Frog   444 ------------------------------------RCQYYTARF--SHKAKYYTLYCYGPGIPI 470

  Fly   594 SILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAM 658
            ..|:                        ||...|.           :.|:::|:.|:..:....|
Frog   471 VTLH------------------------EGFTNKE-----------IQILEDNSNLEATLRNFQM 500

  Fly   659 PQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSK 723
            |..|...: :........::.|||.....:  :||.:::||.||.||.|...:.|.::|||:.::
Frog   501 PSEKIGKI-VQNDKTFWYKMTLPPHFNPRK--KYPLLIYVYGGPSSQEVKATFSVGYSTYLASTE 562

  Fly   724 DYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQL-EVSEYLRDNLHFIDSRRMGVWGWSYGGY 787
            ..||..:||||:|.||.:.:|.:||:||:|||.||: ...:::  .:.|||.:|:.:||||||||
Frog   563 GIIVASLDGRGTAYQGDKFMHAIYKKLGTVEVEDQIFAARKFI--TMGFIDEKRIAIWGWSYGGY 625

  Fly   788 TAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQ 852
            ..::.|.....:|:||::|:||:||:.|.|.|.|||:..|..:||.:.|:.|.:....:..|...
Frog   626 VTSMVLGQGTGLFKCGMAVAPVSNWEYYASIYTERYMGLPTKSDNLENYKNSTVMTRAEQFRKVD 690

  Fly   853 FLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSG-VKRHLYRSMTAFFEDCF 914
            :||||||||||||.||:..::::|....|.::...|.|:.||||| .|.||:..||.|.:.||
Frog   691 YLLVHGTADDNVHFQQAAQISKALVEAQVDFQAMWYTDKDHSLSGSAKTHLFTHMTHFLKQCF 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	116/395 (29%)
		DAP2	<641..916	CDD:224423	105/276 (38%)
		Peptidase_S9	711..916	CDD:278741	87/206 (42%)
fap	NP_001107145.1	DPPIV_N	103..469	CDD:366374	127/483 (26%)
fap	NP_001107145.1	Peptidase_S9	550..754	CDD:366030	87/206 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3093
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920