DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11319 and dpp6a

DIOPT Version :9

Sequence 1:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_009295542.1	Gene:	dpp6a / 100007104	ZFINID:	ZDB-GENE-090918-4	Length:	810	Species:	Danio rerio

Alignment Length:	925	Identity:	278/925 - (30%)
Similarity:	428/925 - (46%)	Gaps:	181/925 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQHS 74
            |||.|||.||||:||.||||||:::.:||||||:||||.::......:::.:::|....|.....
Zfish    30 ELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPGEDDSLAFKEKVTVEEIFKKDFKVHDP 94

  Fly    75 NGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLF 139
            |..||...|.||:...|.:...|.......:|::|..|:......:.:|.|.:.:|||.||..::
Zfish    95 NAKWISNNELLYRTREGDVVRFNMETNESTILVTNRKFEMYKASKYEVSPDMKLVLLAYNVQLVY 159

  Fly   140 RHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVH 204
            .||:.|.|.:..::|.|:..|  :|.:....:|.||.:.|.|..|:::...:||||..|.:.|:
Zfish   160 EHSFTADYIICSLETPETWIL--NPPEVRNAHLQYAGWGPRGQQLIFIFENNIYYRATVENRSI- 221

  Fly   205 RITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSA 269
            |:......||::||:.|||||.||..::.|.|.|.:|..:.|||.|||.|.......:
Zfish   222 RLVSTGKEGVIFNGLTDWLYEAEIFKSHIAHWWSPDGARLAYATINDTLVPRMEIPMF------- 279

  Fly   270 GGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHIT 334
                           ||           ||||..|...|||.|.:||.::|.|.:|..||  |..
Zfish   280 ---------------TG-----------SLYPTARQYHYPKAGEENPVISLYVVNLNGPL--HTI 316

  Fly   335 DLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGWVD 399
            ::..|:.....::|.:...|.:.:|:||.||||.||||::::|.|....|.:.|  ..:..||:.
Zfish   317 EMRRPEDQRIGEYYVTMVKWATSTKLAVNWLNRAQNISILTLCVATTGVCTKKH--EDESEGWLH 379

  Fly   400 TV-AVPLFAANASIYVAISPLRDGLFGYFRHIV---------HVDI-------DKNRVLPLTHGP 447
            .. ..|||:            :|||..:|...:         |:.:       ..:.:..:|.|.
Zfish   380 RQNEEPLFS------------KDGLRLFFTRAIPQGGRGKFFHISMSISQPNSSTDTLQSITSGD 432

  Fly   448 YEVNRLLHWDQLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDE 512
            ::|.::|.:|:....||||.| |..|.::|||....:    |...|.  ||:|
Zfish   433 WDVTQVLAYDEESQLIYFLST-EDDPKRRHLYSADTV----GTFNRR--CLSC------------ 478

  Fly   513 GHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISR 577
                           |:.||                                 |.|....|  |.
Zfish   479 ---------------DFTDS---------------------------------CGYVSGSF--SP 493

  Fly   578 QAKYVLIDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVI 642
            ...|.|::|.||.||.:.:|               ||...:              |.|.:||
Zfish   494 TMDYFLLNCKGPGVPYAAVY---------------STHYRQ--------------KVQDIEL--- 526

  Fly   643 VQNNTRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLV 707
               |..|:.|:....||:::...:.|. .|...|::..|...  .:.:.||.:|.|...||||.|
Zfish   527 ---NLNLRRKVNSMQMPRVEYREINIE-DYSLSVQILKPAGF--IDTSHYPLLLLVDGTPGSQSV 585

  Fly   708 TDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFI 772
            ::.:|:||.:.|..|...:.|..|||||..||..|||:|.:|||..|..|||:|...:... .:|
Zfish   586 SEQFHIDWASVLVSSFGVVAVRFDGRGSGFQGTNLLHKVQRRLGMFEEKDQLDVLSIMMQE-QYI 649

  Fly   773 DSRRMGVWGWSYGGYTAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYE 837
            |..|:|.:|..||||..:|.|:.:.|:.:|...:||:|::.||.|.::||||..|.  .:.:.||
Zfish   650 DKTRIGAFGQVYGGYITSLLLSSEDSMLKCAAVLSPITDFALYASAFSERYLGPPK--PDRRAYE 712

  Fly   838 ESDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSG--VKR 900
            .::|:.......|::||::|.|||:.||.|.:......|.|:...|..||||||||.:..  .::
Zfish   713 MANLAYRASQFIDKKFLIIHPTADEKVHFQHTAKFISRLISERANYSLQIYPDEGHFIHNELTRQ 777

  Fly   901 HLYRSMTAFFEDCFK 915
            ||.:|:..|||:||:
Zfish   778 HLSQSLVNFFEECFR 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	117/397 (29%)
		DAP2	<641..916	CDD:224423	99/277 (36%)
		Peptidase_S9	711..916	CDD:278741	81/207 (39%)
dpp6a	XP_009295542.1	DPPIV_N	143..509	CDD:279298	130/486 (27%)
dpp6a	XP_009295542.1	Abhydrolase	589..791	CDD:304388	79/204 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1679
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970