DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ent2 and Slc29a1

DIOPT Version :9

Sequence 1:	NP_001285680.1	Gene:	Ent2 / 33921	FlyBaseID:	FBgn0263916	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001186042.1	Gene:	Slc29a1 / 63959	MGIID:	1927073	Length:	460	Species:	Mus musculus

Alignment Length:	453	Identity:	139/453 - (30%)
Similarity:	213/453 - (47%)	Gaps:	55/453 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PKDKFLIVFFIFLLHGVGTLMPWNMFITAKSYF------------------EDFKFGPNNTVA-- 95
            |:|::..|:.||.:.|:|||:|||.|:||..||                  |..|...:.|||
Mouse     7 PQDRYKAVWLIFFVLGLGTLLPWNFFMTATKYFTNRLDVSQNVSSDTDQSCESTKALADPTVALP 71

  Fly    96 TEVSYRTHFMQNMGFASQIPNLVFNWLNIFVNFGGDLTTRIVYSIIFEMVILLVTIILAMLDSSQ 160
            ...|....|...|...:.:|.|||..||.|::.....:.||:.|::..:::.|||..|..::...
Mouse    72 ARSSLSAIFNNVMTLCAMLPLLVFTCLNSFLHQRISQSVRILGSLLAILLVFLVTAALVKVEMDA 136

  Fly   161 WPGVFFWTTMVCIVLLNVCNGIYQNTIYGIVASLPIKYTGAVVLGSNISGCFTTAMALICGEIFS 225
            .  :||..||:.|||:|....|.|.:::|:...||..||..::.|..::| |.|::|:||.....
Mouse   137 L--IFFVITMIKIVLINSFGAILQASLFGLAGVLPANYTAPIMSGQGLAG-FFTSVAMICAIASG 198

  Fly   226 SKRT-SAIYYFVTAILVLLLCFDTYFALPLNKFFRHYETISRSSEKKSDSKAQL----------- 278
            |:.: ||..||:||..|::|....|.|||..:|:|||..::.:...:.::|..|
Mouse   199 SELSESAFGYFITACAVVILAILCYLALPRTEFYRHYLQLNLAGPAEQETKLDLISKGEEPKGRR 263

  Fly   279 ---------------NVPYWQIFKKAAPQLFNIFLTFFVTLSVFPAIQSNVHRSDPNFVVGPDYF 328
                           |.....|.|.......::...|.||:.:|||:.:.|..|.........||
Mouse   264 EESGVPGPNSPPTNRNQSIKAILKSICVPALSVCFIFTVTIGLFPAVTAEVESSIAGTSPWKSYF 328

  Fly   329 TLVTCFATFNVFAMLGSLTTSWVQWPGPRFLWVPVVL--RLAFIPLFVMCNYVPP--DSVRSLAV 389
            ..|.||..||||..||...|:...|||....|:||::  |:.||||.::||....  .:.|...|
Mouse   329 IPVACFLNFNVFDWLGRSLTAVCMWPGQDSRWLPVLVASRIVFIPLLMLCNVKARHCGAQRHHFV 393

  Fly   390 FIENDWVYWGIGIAMAYSSGYLSSLGMMYAPQTVHTKYQTTAGMYAAAMLITGIFSGVLFSYL 452
            |..:.| :.....|.|:|:|||:||.|.:.|:.|......|||...:..|..|:..|.:.|:|
Mouse   394 FKHDAW-FIAFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLSFL 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent2	NP_001285680.1	Nucleoside_tran	62..457	CDD:301621	135/442 (31%)
Slc29a1	NP_001186042.1	2a57	18..460	CDD:273352	135/442 (31%)
Slc29a1	NP_001186042.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..277		0/21 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3732
OMA	1	1.010	-	-		QHG53699
OrthoDB	1	1.010	-	-		D318009at33208
OrthoFinder	1	1.000	-	-		FOG0000541
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100863
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2123
SonicParanoid	1	1.000	-	-		X296
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.600