DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ent2 and slc29a4b

DIOPT Version :9

Sequence 1:	NP_001285680.1	Gene:	Ent2 / 33921	FlyBaseID:	FBgn0263916	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_021326781.1	Gene:	slc29a4b / 570283	ZFINID:	ZDB-GENE-121214-93	Length:	521	Species:	Danio rerio

Alignment Length:	512	Identity:	117/512 - (22%)
Similarity:	212/512 - (41%)	Gaps:	106/512 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GKQQAPVTLNPSWESKLPPHDSNGKGSTSVLAKLGLPAPKDKFLIVFFIFLLHGVGTLMPWNMFI 77
            |:::..:| |.|: |:||..:..|:.............|.|::..::|..||.|||.|:|:|.||
Zfish    12 GREKTVIT-NFSF-SQLPEEEKTGRRKPHSAHDSDESIPDDRYHSIYFAMLLAGVGFLLPYNSFI 74

  Fly    78 TAKSYF-EDFKFGPNNTVATEVSYRTHFMQNMGFASQIPNLVFNWLNIFVNFGGDLTTRIVYSII 141
            |...|. ..||   ..::..::|. |:.:..:. |..:.|.:...|:        |.|||....:
Zfish    75 TDVDYLHRKFK---GTSIVFDMSL-TYILVALS-AVIVNNALVERLS--------LHTRICVGYL 126

  Fly   142 FEMVILLVTIILAMLDSSQWPGVF-----FWTTMVCIVLLNVCNGIYQNTIYGIVASLPIKYTGA 201
            |.:..|:...:..:     |..:|     :..|:..:.::.....:.|::.||....||.:||..
Zfish   127 FALGPLVCVSVFDV-----WLELFNTQQSYAVTLAAVAIVAFGCTVQQSSFYGYTGMLPKRYTQG 186

  Fly   202 VVLGSNISGCFTTAMALICGEIFSSKRTSAIYYFVTAILVLLLCFDTYFALPLNKFFRHYETISR 266
            |:.|.:.:|...:...:....:...::.:.|.:|:.::.:..|||..:..:....|.|::.:.:|
Zfish   187 VMTGESTAGVIVSLSRIFTKLLVEDEKNNTIIFFLFSVSMETLCFLLHVVVRRTHFVRYHTSRAR 251

  Fly   267 SS-------------EKKS------DSKAQ------------------------------LNVP- 281
            .|             :|.|      ||.|:                              .:||
Zfish   252 QSHSWLKGQINNVTTQKHSGYQIHYDSSAEEEDGMASSMVDDADAVNLGNGSHGDGIYVRFDVPK 316

  Fly   282 -----YWQIFKKAA-----------PQLFNIFLTFFVTLSVFPAIQSNVHRSDPNFVVGPDYFTL 330
                 .|...|:..           |.:.:|.:|:|:||.:||.::|.:|    |..:| ::..:
Zfish   317 PEAKRSWISVKELLGRRCAVARVIWPYMLSILVTYFITLCLFPGLESELH----NDTLG-EWLPI 376

  Fly   331 VTCFATFNVFAMLGSLTTSW-VQWPGPRFLWVPVVLRLAFIPLFVMCNYVPPDSVRSLAVFIEND 394
            :| .|.||:...:|.:..:. .:|.|.:.| |...||:.|:||||||  |.|.....||   ...
Zfish   377 LT-MALFNMADFVGKILAACPYEWGGVQLL-VCSCLRVLFLPLFVMC--VSPVQRPLLA---HPA 434

  Fly   395 WVYWGIGIAMAYSSGYLSSLGMMYAPQTVHTKYQTTAGMYAAAMLITGIFSGVLFSY 451
            |. .|:.:.:..|:|||.|:.|:.|...|..:.:..||.......:.|:..|...||
Zfish   435 WP-CGLSVMLGISNGYLGSVPMIQAAGKVPLQQREVAGNTMTVSYMAGLMLGSAVSY 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent2	NP_001285680.1	Nucleoside_tran	62..457	CDD:301621	106/463 (23%)
slc29a4b	XP_021326781.1	Nucleoside_tran	60..490	CDD:326577	104/460 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53699
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820