DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ent2 and SLC29A3

DIOPT Version :9

Sequence 1:	NP_001285680.1	Gene:	Ent2 / 33921	FlyBaseID:	FBgn0263916	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_060814.4	Gene:	SLC29A3 / 55315	HGNCID:	23096	Length:	475	Species:	Homo sapiens

Alignment Length:	470	Identity:	140/470 - (29%)
Similarity:	225/470 - (47%)	Gaps:	59/470 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HDSNGKGST----------SVLAKL------GLPAPKDKFLIVFFIFLLHGVGTLMPWNMFITAK 80
            |.||....|          ::|.||      ||..|:|:|...:.||...|:|:|:|||.|||||
Human    11 HSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSLGIGSLLPWNFFITAK 75

  Fly    81 SYFEDFKFGPNNTVAT----EVS-YRTHFMQNMGFASQIPN---LVFNWL---NIFVNFGGDLTT 134
            .|:. ||...:::.||    |.| ...:|...:..||.:|:   ||.|:|   .:.|:.
Human    76 EYWM-FKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLVANFLLVNRVAVHI------ 133

  Fly   135 RIVYSIIFEMVILLVTIILAMLDSSQWPGVFFWTTMVCIVLLNVCNGIYQNTIYGIVASLPIKYT 199
            |::.|:...:.|.:|...|..:|:|.|...||..|:||:|:|:..:.::.::|||:..|.|::.:
Human   134 RVLASLTVILAIFMVITALVKVDTSSWTRGFFAVTIVCMVILSGASTVFSSSIYGMTGSFPMRNS 198

  Fly   200 GAVVLGSNISGCFTTAMALICGEIFSSKRTSAIYYFVTAILVLLLCFDTYFALPLNKFFRHY--- 261
            .|::.|..:.|..:...:|:.....|..|.||:.:|:||.:.|:||...|..|...::.|:|
Human   199 QALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATVFLVLCMGLYLLLSRLEYARYYMRP 263

  Fly   262 ----ETISRSSEKKSDSKAQLNV----------PYWQIFKKAAPQLFNIFLTFFVTLSVFPAIQS 312
                ...|...|...||.:..:|          |...|.||.|...|.:...||:|..::|||.:
Human   264 VLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRPILKKTASLGFCVTYVFFITSLIYPAICT 328

  Fly   313 NVH--RSDPNFVVGPDYFTLVTCFATFNVFAMLGSLTTSWVQWPGPRFLWVP--VVLRLAFIPLF 373
            |:.  ......:....:|..:|.|..:|...:.|...|:|:|.|||....:|  |:||...||||
Human   329 NIESLNKGSGSLWTTKFFIPLTTFLLYNFADLCGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLF 393

  Fly   374 VMCNYVPPDSVRSLAVFIENDWVYWG-IGIAMAYSSGYLSSLGMMYAPQTVHTKYQTTAGMYAAA 437
            |:|||.|  .|....|..::| ||.. :...:..|:||||:|.::|.|:.|..:.....|:..:.
Human   394 VLCNYQP--RVHLKTVVFQSD-VYPALLSSLLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSF 455

  Fly   438 MLITGIFSGVLFSYL 452
            .:..|:..|...|.|
Human   456 YVCLGLTLGSACSTL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent2	NP_001285680.1	Nucleoside_tran	62..457	CDD:301621	127/424 (30%)
SLC29A3	NP_060814.4	Nucleoside_tran	57..475	CDD:301621	127/424 (30%)
SLC29A3	NP_060814.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53699
OrthoDB	1	1.010	-	-		D318009at33208
OrthoFinder	1	1.000	-	-		FOG0000541
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100863
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2123
SonicParanoid	1	1.000	-	-		X296
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.650