DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ent2 and SLC29A1

DIOPT Version :9

Sequence 1:	NP_001285680.1	Gene:	Ent2 / 33921	FlyBaseID:	FBgn0263916	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_011512643.1	Gene:	SLC29A1 / 2030	HGNCID:	11003	Length:	536	Species:	Homo sapiens

Alignment Length:	501	Identity:	149/501 - (29%)
Similarity:	235/501 - (46%)	Gaps:	63/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EAKSEKSPFIGKQQAPVTLNPSWESKLPPHDSNGKGST-SVLAKLGLPAPKDKFLIVFFIFLLHG 66
            :|::|:|     .|......|....:.|...|...|.| :.:.......|:|::..|:.||.:.|
Human    43 QAETEES-----WQGLARKTPGKACQAPEGGSCQPGKTENTITMTTSHQPQDRYKAVWLIFFMLG 102

  Fly    67 VGTLMPWNMFITAKSYFED-FKFGPN-NTVATEVSYRTH------------------FMQNMGFA 111
            :|||:|||.|:||..||.: .....| :.|..|:|....                  |...|...
Human   103 LGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLC 167

  Fly   112 SQIPNLVFNWLNIFVNFGGDLTTRIVYSIIFEMVILLVTIILAMLDSSQWPGVFFWTTMVCIVLL 176
            :.:|.|:|.:||.|::.....:.||:.|::..:::.|:|.||..:.....|  ||..||:.|||:
Human   168 AMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALP--FFVITMIKIVLI 230

  Fly   177 NVCNGIYQNTIYGIVASLPIKYTGAVVLGSNISGCFTTAMALICGEIFSSKRT-SAIYYFVTAIL 240
            |....|.|.:::|:...||..||..::.|..::| |..::|:||.....|:.: ||..||:||..
Human   231 NSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAG-FFASVAMICAIASGSELSESAFGYFITACA 294

  Fly   241 VLLLCFDTYFALPLNKFFRHYETISRSSEKKSDSKAQL----------------NVPYWQ----- 284
            |::|....|..||..:|:|:|:.:......:.::|..|                :|...|
Human   295 VIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNES 359

  Fly   285 -----IFKKAAPQLFNIFLTFFVTLSVFPAIQSNVHRSDPNFVVGPDYFTLVTCFATFNVFAMLG 344
                 |.|..:...|::...|.:|:.:|||:...|..|.........||..|:||.|||:|..||
Human   360 HSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLG 424

  Fly   345 SLTTSWVQWPGPRFLWVP--VVLRLAFIPLFVMCNYVPPDSVRSLAVFIEND-WVYWGIGIAMAY 406
            ...|:...|||....|:|  |:.||.|:||.::||..|.   |.|.|..|:| |..:.:. |.|:
Human   425 RSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPR---RYLTVVFEHDAWFIFFMA-AFAF 485

  Fly   407 SSGYLSSLGMMYAPQTVHTKYQTTAGMYAAAMLITGIFSGVLFSYL 452
            |:|||:||.|.:.|:.|......|||...|..|..|:..|.:||:|
Human   486 SNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent2	NP_001285680.1	Nucleoside_tran	62..457	CDD:301621	136/441 (31%)
SLC29A1	XP_011512643.1	2a57	98..536	CDD:273352	136/441 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147102
Domainoid	1	1.000	66	1.000	Domainoid score	I9927
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3732
OMA	1	1.010	-	-		QHG53699
OrthoDB	1	1.010	-	-		D318009at33208
OrthoFinder	1	1.000	-	-		FOG0000541
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100863
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2123
SonicParanoid	1	1.000	-	-		X296
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.700