DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ent2 and ent-3

DIOPT Version :9

Sequence 1:	NP_001285680.1	Gene:	Ent2 / 33921	FlyBaseID:	FBgn0263916	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_506521.2	Gene:	ent-3 / 179926	WormBaseID:	WBGene00010510	Length:	729	Species:	Caenorhabditis elegans

Alignment Length:	416	Identity:	150/416 - (36%)
Similarity:	234/416 - (56%)	Gaps:	29/416 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KDKFLIVFFIFLLHGVGTLMPWNMFITAK-SYFEDFKFGPNNTVATEVSYRTHFMQNMGFASQIP 115
            ||....|||||::.|.|.|:|||||:... .|:..||....:..||  .|.::|..:|..::|||
Worm   317 KDLGNYVFFIFMMFGFGALLPWNMFLNISFDYYTMFKLRSADGNAT--WYSSNFQNSMTISAQIP 379

  Fly   116 NLVFNWLNIFVNFGGDLTTRIVYSIIFEMVILLVTIILAMLDSSQWPGVFFWTTMVCIVLLNVCN 180
            :|||:.:|||:...||||..:...:|...::::||::...:|:|.|...|...|:..||:||..|
Worm   380 SLVFSVINIFIAVKGDLTRGMKICLIVVQLMVIVTVVFIYIDTSTWIATFSMLTLGTIVVLNAAN 444

  Fly   181 GIYQNTIYGIVASLPIKYTGAVVLGSNISGCFTTAMALICGEIFSSKRTSAIYYFVTAILVLLLC 245
            |::||:::|:.:..|.|||.||::|.|..|...|.::::........:..|..:|..:.:.:::|
Worm   445 GLFQNSMFGLASPFPFKYTNAVIIGQNFCGTAVTVLSMLTKAASDDVQMRASLFFGLSSVAVVVC 509

  Fly   246 FDTYFALPLNKFFRHYETISRSSEKKSDSKAQLNVPYWQ----IFKKAAPQLFNIFLTFFVTLSV 306
            |.....|....|::.:..:..||:  ||.:   .:..|:    .|:|:..|..|||:.|||||::
Worm   510 FILLNFLKRLAFYKKFGILRTSSQ--SDEE---GISSWESVKLAFEKSKMQFANIFVLFFVTLAL 569

  Fly   307 FP--------AIQSNVHRSDPNFVVGPDYFTLVTCFATFNVFAMLGSLTTSWVQWPGPRFLWVPV 363
            ||        |.:..:|    :|||...||..|..|..||:||.||||..:|:::|||..:|:.|
Worm   570 FPNVCMYVKDAKKGELH----SFVVPEKYFMDVVTFLNFNLFAFLGSLMANWIRFPGPNTVWICV 630

  Fly   364 VLRLAFIPLFVMCNYVPPDSVRSLAVFIENDWVY-WGIGIAMAYSSGYLSSLGMMYAPQTVH--T 425
            ..|..|:..|...||.|.|..|:..|..|:.|:: :.|.| .|.:|||||||.|||||:: |  .
Worm   631 AARFWFMFYFPAANYHPMDFPRAYPVLFESTWLFAFNICI-FALTSGYLSSLIMMYAPRS-HEDP 693

  Fly   426 KYQTTAGMYAAAMLITGIFSGVLFSY 451
            |.|..|||.|:..||.||.:|::||:
Worm   694 KIQRMAGMIASFFLIFGIVAGLVFSW 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent2	NP_001285680.1	Nucleoside_tran	62..457	CDD:301621	144/406 (35%)
ent-3	NP_506521.2	ChlI	121..234	CDD:304493
ent-3	NP_506521.2	Nucleoside_tran	434..723	CDD:250824	106/297 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159267
Domainoid	1	1.000	226	1.000	Domainoid score	I1433
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130957
Inparanoid	1	1.050	318	1.000	Inparanoid score	I1507
Isobase	1	0.950	-	0	Normalized mean entropy	S3732
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318009at33208
OrthoFinder	1	1.000	-	-		FOG0000541
OrthoInspector	1	1.000	-	-		otm14143
orthoMCL	1	0.900	-	-		OOG6_100863
Panther	1	1.100	-	-	O	PTHR10332
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2123
SonicParanoid	1	1.000	-	-		X296
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740