DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IFT52 and IFT52

DIOPT Version :9

Sequence 1:	NP_609045.2	Gene:	IFT52 / 33917	FlyBaseID:	FBgn0031829	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001290387.1	Gene:	IFT52 / 51098	HGNCID:	15901	Length:	437	Species:	Homo sapiens

Alignment Length:	436	Identity:	161/436 - (36%)
Similarity:	256/436 - (58%)	Gaps:	33/436 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KPVICFDTSKNERFQISDNYKMMHRKLKVNWNVEQNDAELRMERLARVKIFVLAGPQDRFTEDEF 68
            :..|.|:..|.|.|..::.||.|.:||:.||.::....|:..|:|..||:::.|||:::||..||
Human     6 RSTILFNAYKKEIFTTNNGYKSMQKKLRSNWKIQSLKDEITSEKLNGVKLWITAGPREKFTAAEF 70

  Fly    69 DVLKHYVEVQGGSLVVLLGEGGEPEFNTNVNFFLEQYGIYINGDTVVRPHYYKNFHPKECIVGGG 133
            ::||.|::. ||.:.|:||||||..|:||:||.||:|||.:|.|.|||..|:|.|||||.:|..|
Human    71 EILKKYLDT-GGDVFVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYHKYFHPKEALVSSG 134

  Fly   134 VVCESMWRHLLK-----LDIEKVYYDFSDEKYKIHFQYPYGATLNVSEPANVLLTTGPVVYPFNR 193
            |:...:.|...|     :|.|    ...:....:.|.||:||||:|.:||..:|:||.|.:|.||
Human   135 VLNREISRAAGKAVPGIIDEE----SSGNNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNR 195

  Fly   194 PLVG-YFTNGKGGKILAVGSGYIWHDKYLQDKTNDAMFEYLIKLLGGDEITYSHLDFNDVELSDN 257
            |::. |.:..:|||:..:||.:::.|:||..:.|..:.:.:.:.|...:|..:.:|..|.|:||.
Human   196 PILAFYHSKNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLNQIDAEDPEISDY 260

  Fly   258 KHFTDIGFLADMPKACLIDSIGTDMPTDFKQMFDMRLCRLSNRLLKDVMDTYEQLHVKYEPLKII 322
            ........|:...:.||.:|  .::|.||..:||:.:.:|.......|::.:|||:||:|||::|
Human   261 MMLPYTATLSKRNRECLQES--DEIPRDFTTLFDLSIFQLDTTSFHSVIEAHEQLNVKHEPLQLI 323

  Fly   323 KPQFEIPLPNVQLATFPPIFSEPSAPPLELYDLDETFSGARSQLAHMTGQVLQALQSKEPQRRAL 387
            :||||.|||.:|.|.|||.|.|...|||||:|||||||..:::||.:|.:              .
Human   324 QPQFETPLPTLQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNK--------------C 374

  Fly   388 NQRELENYIKECARITAIVD----ERQDMAAREILNIVARQIISYR 429
            .:.:||.|:::|..|..:..    ::||  |:.||..|..|::.::
Human   375 TEEDLEFYVRKCGDILGVTSKLPKDQQD--AKHILEHVFFQVVEFK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IFT52	NP_609045.2	ABC_transp_aux	<1..115	CDD:420021	48/110 (44%)
IFT52	NP_001290387.1	ABC_transp_aux	<2..116	CDD:329091	48/109 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159670
Domainoid	1	1.000	190	1.000	Domainoid score	I3279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9335
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2760
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56686
OrthoDB	1	1.010	-	-		D284059at33208
OrthoFinder	1	1.000	-	-		FOG0008331
OrthoInspector	1	1.000	-	-		oto90646
orthoMCL	1	0.900	-	-		OOG6_104610
Panther	1	1.100	-	-	LDO	PTHR12969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5524
SonicParanoid	1	1.000	-	-		X6312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940