Protein Alignment eya and eya1

DIOPT Version :10

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: XP_017950627.1
• Gene: eya1 / 779594
• XenbaseID: XB-GENE-479279
• Length: 605
• Species: Xenopus tropicalis
• Alignment Length: 719
• Identity: 287/719 - (39%)
• Similarity: 368/719 - (51%)
• Gaps: 208/719 - (28%)

  Fly    70 HQQSHSSTVLASNGPSSAGAGMGVGVGGGGGSGGGVGGGVGQCSPLGLPPQSQPLQPTIGSLASL 134
            |..:.|.:|:.|:|.|                                |.|:|...|.|
 Frog    73 HLDNFSGSVIGSSGYS--------------------------------PRQAQQFSPQI------ 99

  Fly   135 SGHYSNGNANPNV--NSSSCSLA----TASSFAQSAGSSFSTYQQAGGTSG---------GVSGE 184
               |.:..|.|::  |.||.::|    |..|......::::||.|.|...|         |:..|
 Frog   100 ---YPSNRAYPHILPNPSSQTMAAYGQTQFSSGMQQATAYATYPQPGQPYGIPPYGALWAGIKTE 161

  Fly   185 DGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAV 249
            .|:                      .:.:||||          .|...|| ||.|.|..|.|
 Frog   162 GGL----------------------PQPQSPGQ----------TGFLSYG-SSFSTPQPGQA--- 190

  Fly   250 NSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAAAAAAAYLT 314
                                          |..|...|:.:..|:          ...|.:..||
 Frog   191 ------------------------------PYSYQMQGSSFTTAS----------GIYAGSNSLT 215

  Fly   315 PSYAASGNNNSQLYSSPYAGYNNFGQQDYGGYYNEQ-YGNYY-SPANYSPYAVSSPSSSASHGHG 377
            .|   :|.|:||   ..|..|.:|||..|..|||.. |.::| :.:|.||   ::||::|:  :.
 Frog   216 NS---TGFNSSQ---QEYPSYPSFGQGQYAQYYNSSPYPSHYMTSSNTSP---TTPSTTAT--YQ 269

  Fly   378 FHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSS 442
            .....|...|::.|| |||.. :.|.|||.:|:..|.|.                ....||.|.|
 Frog   270 LQEPPSGITSQAVTD-HSTAE-YSTIHSPSTPIKDSDSD----------------RLRRSSDGKS 316

  Fly   443 VGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPP----ERVFVWDLDET 503
                                 |.||||:..|||               ||    ||||:||||||
 Frog   317 ---------------------RGRGRRNNNPSP---------------PPDSDLERVFIWDLDET 345

  Fly   504 LIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQ 568
            :|:||:||:|||||||.:|..:.:::..|||||:||:||||.|||::||||||||||||||||||
 Frog   346 IIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQ 410

  Fly   569 DLSAYNFATDGFHTNTPPGA-PPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGP 632
            |||.|||.||||    |..| ..||||.||||||||||||||||||::|:|||:|:.|||.||||
 Frog   411 DLSTYNFGTDGF----PAAATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGP 471

  Fly   633 GKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNI 697
            .|||||||:|:|||..||:|.|||||.|::|..|.||||:|||:|||.||||||||:|||.:|.|
 Frog   472 AKREAWLQLRAEIEALTDSWLTLALKALTLIHSRSNCVNILVTTTQLIPALAKVLLYGLGIVFPI 536

  Fly   698 ENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALD 762
            ||||||.|||.|:|:|||:.|||||..|||:|||.|||..||..:.|||||::|||:.||:.||:
 Frog   537 ENIYSATKIGKESCFERIIQRFGRKVVYVVVGDGVEEEQGAKKHSMPFWRITSHSDLMALHHALE 601

  Fly   763 MGFL 766
            :.:|
 Frog   602 LEYL 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	HAD_Eya	492..766	CDD:319789	189/278 (68%)
eya1	XP_017950627.1	HAD_Eya	334..605	CDD:319789	188/274 (69%)