Protein Alignment eya and eya2

DIOPT Version :9

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_001004558.1
• Gene: eya2 / 447819
• ZFINID: ZDB-GENE-040912-24
• Length: 475
• Species: Danio rerio
• Alignment Length: 595
• Identity: 238/595 - (40%)
• Similarity: 321/595 - (53%)
• Gaps: 153/595 - (25%)

  Fly   189 GGATVMSHWTHDGTGSSAAVKSE---SRSPGQVHASL------DNGSVAGSNLYGCSSASNPLDG 244
            |..|..:|.|...:.:|..:|:|   |.||||  :||      .:|:..|..||..|      .|
Zfish    17 GPYTPYTHHTQGYSMTSYNIKTEDGLSHSPGQ--SSLLGYTPNFSGTPPGQTLYSYS------HG 73

  Fly   245 GAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAAAAA 309
            |::          ::.::.|.      ||:         :| .||::.|
Zfish    74 GSI----------SSGIFQGA------NSI---------TG-STPFSPA---------------- 96

  Fly   310 AAYLTPSYAASGNNNSQLYSSPYAGYNNFGQQDYGGYYNEQYGN-YYSPANYSPYAVSSPSSSAS 373
                               ...::.|:::.|..|..|||..|.: |.:.:|.:|.|:   :::..
Zfish    97 -------------------QQDFSTYSSYSQSQYSPYYNTHYNSPYITASNITPSAI---TTAIP 139

  Fly   374 HGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSS 438
            :.|..|.|.|:|  .||   .|.|..:|...||  |.|.....|:
Zfish   140 YQHTDHPAVSTN--HSP---ESHTAEYQAPTSP--PTPGKDQDGA-------------------- 177

  Fly   439 GGSSVGTAGSGGVATSKTTPTGKT--GRARGRRHQQPSPTRSTASDTGNSEAVKPP-----ERVF 496
                               |..::  |:.|||:.         |||.      .||     ||||
Zfish   178 -------------------PPRRSADGKLRGRKR---------ASDP------VPPLDSDIERVF 208

  Fly   497 VWDLDETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDV 561
            |||||||:||||:||:|:::.|:.||....:::...||||:||:||:..|||::|||||||||||
Zfish   209 VWDLDETIIIFHSLLTGTFSTRFGKDSGKAVSLGLWMEEMIFNLADSRLFFNDLEECDQVHIDDV 273

  Fly   562 SSDDNGQDLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNV 626
            :|||||||||.|||.||||.|   |....:|||.:||.||||||||||||||::|:|||:|:.||
Zfish   274 ASDDNGQDLSTYNFGTDGFQT---PAGGGSLCLGSGVHGGVDWMRKLAFRYRRVKEIYNTYKNNV 335

  Fly   627 GTLLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGL 691
            |.|||..|||.|||:|.|:||.||.|.|.|||.|::|:.|.||||||||:|||.|||:||||:||
Zfish   336 GGLLGSPKREEWLQLRREMEVLTDLWLTQALKALALINSRPNCVNVLVTTTQLIPALSKVLLYGL 400

  Fly   692 GGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRA 756
            ||.|.|||||||.|.|.|:|:||:..||||::.|||:|||.||||.||..|.||||::..:|:.|
Zfish   401 GGAFPIENIYSATKTGKESCFERVTQRFGRRAVYVVVGDGIEEETVAKKKNMPFWRVTCRADLEA 465

  Fly   757 LYTALDMGFL 766
            |..||::.:|
Zfish   466 LSHALELDYL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	9/73 (12%)
		EYA-cons_domain	492..766	CDD:273739	174/278 (63%)
eya2	NP_001004558.1	EYA-cons_domain	204..475	CDD:273739	173/273 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	335	1.000	Domainoid score	I1098
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1646
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm25587
orthoMCL	1	0.900	-	-		OOG6_102363
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820