DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eya and Eya3

DIOPT Version :9

Sequence 1:	NP_723188.1	Gene:	eya / 33916	FlyBaseID:	FBgn0000320	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_038965712.1	Gene:	Eya3 / 313027	RGDID:	1309932	Length:	607	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	244/627 - (38%)
Similarity:	328/627 - (52%)	Gaps:	137/627 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 KSESRSPG-QVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYN 272
            |::.:.|| |..:.::|...:.......|.|||       ...|..:......:....:||
  Rat    49 KAKMQEPGEQTLSQVNNPDTSDQKPETASLASN-------LSMSEEIMTCTDYIPRSSNDY---- 102

  Fly   273 SMQQYTPPPF------------YSG---YGT-----PYAAATAARQ-------AKMEPGAAAAAA 310
            :.|.|:..|:            |.|   |.|     |||....|.|       ..:.||....:.
  Rat   103 TSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFGALWPGMKPESG 167

  Fly   311 AYLTPS----------------------YA----ASGNNNSQLYSS------PYAGYNNFGQQDY 343
            ...|||                      |:    ||..|.|.:.:|      |.|...:...|||
  Rat   168 LIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIPASSTNASLISTSSAIANIPAAAVASISNQDY 232

  Fly   344 GGYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHS 408
                     ..|:....:.|....||||      |.|...:|     :||.:|. :..||:....
  Rat   233 ---------PTYTILGQNQYQACYPSSS------FGVTGQTN-----SDTENTA-LAATTYQTEK 276

  Fly   409 PLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPT---------GKTGR 464
            |        ..:||      |.|...|.|...:|        ...|:|||.         ..|.:
  Rat   277 P--------GAMGP------APATQRLPSDSSTS--------PPLSQTTPNKDADDQARKNMTVK 319

  Fly   465 ARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMTI 529
            .||:|       ::.||.:.:||.    ||||:||||||:||||:||:||||.:|.||.:.::..
  Rat   320 NRGKR-------KADASSSQDSEL----ERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGS 373

  Fly   530 AFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNLCL 594
            ...||||:|.:||||.|||::|||||||::||:|||||||||.|:|:||||..:...|:..:
  Rat   374 GLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGS--- 435

  Fly   595 PTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALKC 659
            ..||:|||||||||||||||:::||:.::.|||.||.|.::||..::|:||||.||:|...|||.
  Rat   436 SVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKS 500

  Fly   660 LSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKST 724
            |.:|..|:||||||:|:|||.||||||||:|||.||.|||||||.|||.|:|:||||:|||:|.|
  Rat   501 LLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVT 565

  Fly   725 YVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL 766
            |||||||.:||.|||..|.|||||:.|.|:.:|:.||::.||
  Rat   566 YVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	17/80 (21%)
eya	NP_723188.1	EYA-cons_domain	492..766	CDD:273739	168/273 (62%)
Eya3	XP_038965712.1	Herpes_BLLF1	<164..>304	CDD:282904	38/182 (21%)
Eya3	XP_038965712.1	EYA-cons_domain	336..607	CDD:273739	168/277 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	422	1.000	Inparanoid score	I1722
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm46133
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.890