DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eya and eya1

DIOPT Version :9

Sequence 1:	NP_723188.1	Gene:	eya / 33916	FlyBaseID:	FBgn0000320	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_009295600.2	Gene:	eya1 / 30436	ZFINID:	ZDB-GENE-990712-18	Length:	614	Species:	Danio rerio

Alignment Length:	723	Identity:	284/723 - (39%)
Similarity:	368/723 - (50%)	Gaps:	192/723 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SQPLQPTIGSLASLSG------HYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSG 179
            :.|.....||..|.:|      |.:|.:..||                             ||.|
Zfish     7 ASPHSRVSGSSESPNGPNIDNSHINNNSMTPN-----------------------------GTEG 42

  Fly   180 GVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDG 244
                 |.:....|  :.|....:..|||||:|..|..::..|:.:||:            :...|
Zfish    43 -----DNITMLTT--ADWLLSSSSQSAAVKTEPMSSSEIATSVADGSL------------DSFSG 88

  Fly   245 GAVAVNSSAVAAA---AAAVYDGKHDY------------------YYYNSMQQ------YTPP-- 280
            .|:..:..:....   :..:|.....|                  .|...|||      |..|
Zfish    89 SAIGTSGFSPRQTHQFSPQIYPSNRPYPHILPTPSAQNMAAYGQTQYTTGMQQAAAYGTYPQPGQ 153

  Fly   281 PF-YSGYGTPYA-----AATAARQAKMEPGAAAAAAAYLTP-------SYAASGNNNSQLYSSPY 332
            |: .|.||..:|     ......|:..:.|..:.::::.||       ||...|.:.:.. |..|
Zfish   154 PYGISAYGPLWAGIKTEGGLTQAQSPGQSGFLSYSSSFSTPQTGQAPYSYQMQGGSFTTT-SGLY 217

  Fly   333 AGYN--------NFGQQDYGGY---YNEQYGNYYSPANY-SPYAVS------SPSSSASH----- 374
            ||.|        |..||||..|   ...||..||:.:.| |||..|      :||::|::
Zfish   218 AGSNSLTNSTGFNSTQQDYPSYPTFGQSQYAQYYNSSPYTSPYMTSNNTSPTTPSTTATYTLQEP 282

  Fly   375 --GHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNS 437
              |     ..|..|:|.||..:|      |.|||.:  ||..|....:....:|.|
Zfish   283 PSG-----ITSQALTEQPTGEYS------TIHSPST--PIKDSDSDRLRRASDVKA--------- 325

  Fly   438 SGGSSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPP----ERVFVW 498
                                      |.||||:..|||               ||    ||||:|
Zfish   326 --------------------------RGRGRRNNNPSP---------------PPDSDLERVFIW 349

  Fly   499 DLDETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSS 563
            |||||:|:||:||:||||||:.:|..:.:::..|||||:||:||||||||::|||||||||||||
Zfish   350 DLDETIIVFHSLLTGSYANRFGRDPPTSVSLGLRMEEMIFNLADTHFFFNDLEECDQVHIDDVSS 414

  Fly   564 DDNGQDLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGT 628
            ||||||||.|||:|||||.   .....||||.||||||||||||||||||::|:||.:|:.|||.
Zfish   415 DDNGQDLSTYNFSTDGFHA---AATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYTTYKNNVGG 476

  Fly   629 LLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGG 693
            ||||.|||||||:|:|||..||:|.|||||.|::|..|.||||:|||:|||.||||||||:|||.
Zfish   477 LLGPAKREAWLQLRAEIEALTDSWLTLALKALTLIHSRSNCVNILVTTTQLIPALAKVLLYGLGV 541

  Fly   694 IFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALY 758
            :|.|||||||.|||.|:|:||::.|||||..|||:|||.|||..:|..|.||||||:|||:.||:
Zfish   542 VFPIENIYSATKIGKESCFERVIQRFGRKVVYVVVGDGVEEEQGSKKHNMPFWRISSHSDLMALH 606

  Fly   759 TALDMGFL 766
            .|||:.:|
Zfish   607 HALDLEYL 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	11/71 (15%)
eya	NP_723188.1	EYA-cons_domain	492..766	CDD:273739	188/277 (68%)
eya1	XP_009295600.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1646
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm25587
orthoMCL	1	0.900	-	-		OOG6_102363
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.820