Protein Alignment eya and EYA3

DIOPT Version :9

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: XP_011539301.1
• Gene: EYA3 / 2140
• HGNCID: 3521
• Length: 584
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 234/601 - (38%)
• Similarity: 313/601 - (52%)
• Gaps: 138/601 - (22%)

  Fly   209 KSESRSPG-QVHASLDNGSVAGSNLYGCSSASN-PLDGGAVAVNSSAVAAAAAAVYDGKHDYYYY 271
            |::.:..| |..:.:.|..|:.......|.||| |:        |..:......:....:||
Human    16 KAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPM--------SEEIMTCTDYIPRSSNDY--- 69

  Fly   272 NSMQQYTPPPF------------YSG---YGT-----PYAAATAARQ-------AKMEPGAAAAA 309
             :.|.|:..|:            |.|   |.|     |||....|.|       ..:.||....:
Human    70 -TSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPFGALWPGMKPES 133

  Fly   310 AAYLTPS----------------------YA----ASGNNNSQLYSS------PYAGYNNFGQQD 342
            ....|||                      |:    ||..|.|.:.:|      |.|...:...||
Human   134 GLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSSTIANIPAAAVASISNQD 198

  Fly   343 YGGYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPH 407
            |         ..|:....:.|....||||      |.|...:|     :|..||| :..||:...
Human   199 Y---------PTYTILGQNQYQACYPSSS------FGVTGQTN-----SDAESTT-LAATTYQSE 242

  Fly   408 SPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPT---------GKTG 463
            .|               :|.|.|.||...|||..|...      :.|:|||:         ..|.
Human   243 KP---------------SVMAPAPAAQRLSSGDPSTSP------SLSQTTPSKDTDDQSRKNMTS 286

  Fly   464 RARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMT 528
            :.||:|       ::.|:.:.:||.    ||||:||||||:||||:||:||||.:|.||.:.::.
Human   287 KNRGKR-------KADATSSQDSEL----ERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIG 340

  Fly   529 IAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNLC 593
            ....||||:|.:||||.|||::|||||||::||:|||||||||.|:|:||||..:...|:..:
Human   341 SGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGS-- 403

  Fly   594 LPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALK 658
             ..||:|||||||||||||||:::||:.::.|||.||.|.::||..::|:||||.||:|...|||
Human   404 -SVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALK 467

  Fly   659 CLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKS 723
            .|.:|..|:||||||:|:|||.||||||||:|||.||.|||||||.|||.|:|:||||:|||:|.
Human   468 SLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKV 532

  Fly   724 TYVVIGDGNEEETAAK 739
            ||||||||.:||.|||
Human   533 TYVVIGDGRDEEIAAK 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	18/80 (23%)
		EYA-cons_domain	492..766	CDD:273739	157/248 (63%)
EYA3	XP_011539301.1	HAD_Eya	304..549	CDD:319789	157/252 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1746
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm41992
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.850