Protein Alignment eya and EYA1

DIOPT Version :9

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_001357262.1
• Gene: EYA1 / 2138
• HGNCID: 3519
• Length: 621
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 288/696 - (41%)
• Similarity: 369/696 - (53%)
• Gaps: 142/696 - (20%)

  Fly   112 CSPLGLPPQSQPLQPTIGSLASLSGHYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGG 176
            |..:.:...:.|.....||..|.||. ..||::.|.||.:.:.....:...|:..:.||  .|.|
Human    27 CRSMEMQDLTSPHSRLSGSSESPSGP-KLGNSHINSNSMTPNGTEVKTEPMSSSETAST--TADG 88

  Fly   177 TSGGVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHAS-------LDNGSVAGSNLYG 234
            :....||  ..:|.::.....||            ..||.|::.|       |...|......||
Human    89 SLNNFSG--SAIGSSSFSPRPTH------------QFSPPQIYPSNRPYPHILPTPSSQTMAAYG 139

  Fly   235 -----------CSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGT 288
                       .:.|:.|..|....::|.....|......|.       |..|......:..|||
Human   140 QTQFTTGMQQATAYATYPQPGQPYGISSYGALWAGIKTEGGL-------SQSQSPGQTGFLSYGT 197

  Fly   289 PYAAATAARQAKMEPGAA-----AAAAAYLTPSYAASGNN---NSQLYSS---PYAGYNNFGQQD 342
            .::..        :||.|     ...:::.|.|...:|||   ||..::|   .|..|.:|||..
Human   198 SFSTP--------QPGQAPYSYQMQGSSFTTSSGIYTGNNSLTNSSGFNSSQQDYPSYPSFGQGQ 254

  Fly   343 YGGYYNEQ-Y-GNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHS---TTPV--H 400
            |..|||.. | .:|.:.:|.||   ::||::|::          .|.|.|:...|   |.|.  :
Human   255 YAQYYNSSPYPAHYMTSSNTSP---TTPSTNATY----------QLQEPPSGITSQAVTDPTAEY 306

  Fly   401 QTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTGKTGRA 465
            .|.|||.:|:..|.|.....|                |.|.|                     |.
Human   307 STIHSPSTPIKDSDSDRLRRG----------------SDGKS---------------------RG 334

  Fly   466 RGRRHQQPSPTRSTASDTGNSEAVKPP----ERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSL 526
            ||||:..|||               ||    ||||:||||||:|:||:||:|||||||.:|..:.
Human   335 RGRRNNNPSP---------------PPDSDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTS 384

  Fly   527 MTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGA-PP 590
            :::..|||||:||:||||.|||::|||||||||||||||||||||.|||.||||    |..| ..
Human   385 VSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGF----PAAATSA 445

  Fly   591 NLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATL 655
            ||||.||||||||||||||||||::|:|||:|:.|||.||||.|||||||:|:|||..||:|.||
Human   446 NLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTL 510

  Fly   656 ALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFG 720
            |||.||:|..|.||||:|||:|||.||||||||:|||.:|.|||||||.|||.|:|:|||:.|||
Human   511 ALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFG 575

  Fly   721 RKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL 766
            ||..|||||||.|||..||....||||||:|||:.||:.||::.:|
Human   576 RKVVYVVIGDGVEEEQGAKKHAMPFWRISSHSDLMALHHALELEYL 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	14/71 (20%)
		EYA-cons_domain	492..766	CDD:273739	192/278 (69%)
EYA1	NP_001357262.1	HAD_Eya	350..621	CDD:319789	191/274 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1746
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm41992
orthoMCL	1	0.900	-	-		OOG6_102363
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.820