Protein Alignment eya and EYA4

DIOPT Version :9

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: XP_016865857.1
• Gene: EYA4 / 2070
• HGNCID: 3522
• Length: 654
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 277/691 - (40%)
• Similarity: 352/691 - (50%)
• Gaps: 179/691 - (25%)

  Fly   139 SNGNANPNVNSSSCSLATASS------FAQSAGSS---FSTYQQAGGTSGGVSGEDGVVGGATVM 194
            :..:.:.:.||.|..:...:|      ...:.|||   .|.......|:.|..||:     .||:
Human    17 TESDVSQSQNSRSMEMQDLASPHTLVGGGDTPGSSKLEKSNLSSTSVTTNGTGGEN-----MTVL 76

  Fly   195 SHWTHD-----GTGSSA-----AVKSESRSPGQVHA-----SLD--NGSVAGSNLYGCSSA---- 238
            :  |.|     .|.|||     |||:|..:..:..|     :||  .|||..|:.|...||
Human    77 N--TADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGDGALDTFTGSVITSSGYSPRSAHQYS 139

  Fly   239 -----SNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGY---GTPYAAAT- 294
                 |.|...     ..|..||...:.|.|:..   |:.|||   |..|:.|   |.||:..|
Human   140 PQLYPSKPYPH-----ILSTPAAQTMSAYAGQTQ---YSGMQQ---PAVYTAYSQTGQPYSLPTY 193

  Fly   295 ---------------AARQAKMEPGAAAAAAAYLTP-------SYAASGN----------NNSQL 327
                           :..|:.::.|..:.:..:.||       ||...|:          |||..
Human   194 DLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVS 258

  Fly   328 YSSPYAGYNNFGQQDYGGYY---NEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSES 389
            .|:.::|    .||||..|.   ..||..|||.:.|..|..|:
Human   259 NSTNFSG----SQQDYPSYTAFGQNQYAQYYSASTYGAYMTSN---------------------- 297

  Fly   390 PTDTHSTTPVHQTTHSPHSPLP-ISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVAT 453
              :|...||...:|:.....|| ::...|:.:.|                        |......
Human   298 --NTADGTPSSTSTYQLQESLPGLTNQPGTDLHP------------------------GEFDTMQ 336

  Fly   454 SKTTP-----------TGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPP----ERVFVWDLDET 503
            |.:||           :|...|.|||:: .|||               ||    |||||||||||
Human   337 SPSTPIKDLDERTCRSSGSKSRGRGRKN-NPSP---------------PPDSDLERVFVWDLDET 385

  Fly   504 LIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQ 568
            :|:||:||:||||.:|.||....:|:..|||||:||:||||.|||::||||||||||||||||||
Human   386 IIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQ 450

  Fly   569 DLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPG 633
            |||.|:|||||||.   ..:..|||||||||||||||||||||||::|::||:|:.|||.||||.
Human   451 DLSTYSFATDGFHA---AASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPA 512

  Fly   634 KREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIE 698
            ||:||||:|:|||..||:|.|.|||.||:||.|.||:|||||:|||.||||||||:.|||.|.||
Human   513 KRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLLYSLGGAFPIE 577

  Fly   699 NIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAK 739
            |||||.|||.|:|:|||:.|||||..|||||||.|||.|||
Human   578 NIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAK 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	14/82 (17%)
		EYA-cons_domain	492..766	CDD:273739	179/252 (71%)
EYA4	XP_016865857.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	372	1.000	Domainoid score	I902
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1746
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm41992
orthoMCL	1	0.900	-	-		OOG6_102363
Panther	1	1.100	-	-	LDO	PTHR10190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3984
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890