DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eya and Eya4

DIOPT Version :9

Sequence 1:	NP_723188.1	Gene:	eya / 33916	FlyBaseID:	FBgn0000320	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_017169288.1	Gene:	Eya4 / 14051	MGIID:	1337104	Length:	639	Species:	Mus musculus

Alignment Length:	700	Identity:	294/700 - (42%)
Similarity:	370/700 - (52%)	Gaps:	172/700 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 ANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHD-----GT 202
            |:|:..........:|...:|..||.|.      |:.|..|::     .||::  |.|     .|
Mouse    36 ASPHALVGGSDTPGSSKLDKSGLSSTSV------TTNGTGGDN-----MTVLN--TADWLLSCNT 87

  Fly   203 GSSA-----AVKSESRSPGQVHAS----------LD--NGSVAGSNLYGCSSA---------SNP 241
            .|||     |||:|     .:|:|          ||  .|||..|:.|...||         |.|
Mouse    88 PSSATMSLLAVKTE-----PLHSSESTTTTGDGALDTFTGSVITSSGYSPRSAQQYSPQLYPSKP 147

  Fly   242 LDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGY---GTPYA------------ 291
            ...     ..|..||...:.|.|:..   |:.|||   |..|:.|   |.||:
Mouse   148 YPH-----ILSTPAAQTMSAYAGQTQ---YSGMQQ---PAVYTAYSQTGQPYSLPAYDLGVMLPA 201

  Fly   292 ----AATAARQAKMEPGAAAAAAAYLTP-------SYAASGNN---NSQLY-SSPYAGYNNF--G 339
                :..:..|:.::.|..:.:..:.||       ||...|::   :|.:| ::..:...||  .
Mouse   202 IKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSSS 266

  Fly   340 QQDYGGYY---NEQYGNYYSPANYSPYAVSS-----PSSSASHGHGFHVAASSNLSESPTDTHST 396
            ||||..|.   ..||..|||.:.|..|..|:     .|||.|         :..|.||.....|.
Mouse   267 QQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTSSSTS---------TYQLQESLQGLTSQ 322

  Fly   397 TPVHQTTHSPHSPL-PISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTG 460
            .....|..||.:|: .:...|                  ..|||..|
Mouse   323 PGEFDTVQSPSTPIKDLDDRT------------------CRSSGSKS------------------ 351

  Fly   461 KTGRARGRRHQQPSPTRSTASDTGNSEAVKPP----ERVFVWDLDETLIIFHTLLSGSYANRYTK 521
               |.|||:: .|||               ||    |||||||||||:|:||:||:||||.:|.|
Mouse   352 ---RGRGRKN-NPSP---------------PPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGK 397

  Fly   522 DHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPP 586
            |....:|:..|||||:||:||||.|||::|||||||||||||||||||||.|:|||||||.   .
Mouse   398 DPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHA---A 459

  Fly   587 GAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDN 651
            .:..|||||||||||||||||||||||::|::||:|:.|||.||||.||:||||:|:|||..||:
Mouse   460 ASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDS 524

  Fly   652 WATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIV 716
            |.|.|||.||:||.|.||||||||:|||.||||||||:.|||.|.|||||||.|||.|:|:|||:
Mouse   525 WLTNALKSLSIISTRSNCVNVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIM 589

  Fly   717 TRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL 766
            .|||||..|||||||.|||.|||..|.||||||:|||:.||:.||::.:|
Mouse   590 QRFGRKVVYVVIGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	12/71 (17%)
eya	NP_723188.1	EYA-cons_domain	492..766	CDD:273739	194/277 (70%)
Eya4	XP_017169288.1	PTZ00395	<162..>341	CDD:185594	48/193 (25%)
Eya4	XP_017169288.1	HAD_Eya	368..639	CDD:319789	193/273 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1736
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm44043
orthoMCL	1	0.900	-	-		OOG6_102363
Panther	1	1.100	-	-	LDO	PTHR10190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3984
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.850