Protein Alignment eya and Eya3

DIOPT Version :9

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: XP_006538600.1
• Gene: Eya3 / 14050
• MGIID: 109339
• Length: 572
• Species: Mus musculus
• Alignment Length: 629
• Identity: 240/629 - (38%)
• Similarity: 323/629 - (51%)
• Gaps: 141/629 - (22%)

  Fly   209 KSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNS 273
            |::.:.|.:...|..|...|.......||.::.|.      .|..:......:....:||    :
Mouse    14 KAKMQEPREQTLSQVNNPDASDEKPETSSLASNLS------MSEEIMTCTDYIPRSSNDY----T 68

  Fly   274 MQQYTPPPF------------YSG---YGT-----PYAAATAARQA-------------KMEPG- 304
            .|.|:..|:            |.|   |.|     |||....|.|.             |.|.|
Mouse    69 SQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFGALWPGMKPESGL 133

  Fly   305 --------------------AAAAAAAYLTPSYAASGN-----NNSQLYSSPYAGYNNFGQQDYG 344
                                :..::|.|..|..|:|.|     .:|.:.:.|.|...:...|||
Mouse   134 IQTPSPSQHSVLTCTTGLTTSQPSSAHYSYPIQASSTNASLIPTSSAIANIPAAAVASISNQDY- 197

  Fly   345 GYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSP 409
                    ..|:....:.|....||||      |.|...:| |::.|.|.:.|.......|...|
Mouse   198 --------PTYTILGQNQYQACYPSSS------FGVTGQTN-SDAETTTLAATTYQTEKPSAMVP 247

  Fly   410 LPIS---PSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPT---------GKT 462
            .|.:   ||..|...||                              |:|||.         ..|
Mouse   248 APATQRLPSDSSASPPL------------------------------SQTTPNKDADDQARKNMT 282

  Fly   463 GRARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLM 527
            .:.||:|       ::.||.:.:||.    ||||:||||||:||||:||:||||.:|.||.:.::
Mouse   283 VKNRGKR-------KADASSSQDSEL----ERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVI 336

  Fly   528 TIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNL 592
            .....||||:|.:||||.|||::|||||||::||:|||||||||.|:|:||||..:...|:..:
Mouse   337 GSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGS- 400

  Fly   593 CLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLAL 657
              ..||:|||||||||||||||:::||:.::.|||.||.|.::||..::|:||||.||:|...||
Mouse   401 --SVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTAL 463

  Fly   658 KCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRK 722
            |.|.:|..|:||.|||:|:|||.||||||||:|||.||.|||||||.|||.|:|:||||:|||:|
Mouse   464 KSLLLIQSRKNCANVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKK 528

  Fly   723 STYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL 766
            .||||||||.:||.|||..|.|||||:.|.|:.:|:.||::.||
Mouse   529 VTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	15/83 (18%)
		EYA-cons_domain	492..766	CDD:273739	167/273 (61%)
Eya3	XP_006538600.1	Med15	<8..>139	CDD:312941	26/134 (19%)
		EYA-cons_domain	301..572	CDD:273739	167/277 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1736
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm44043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.850