Protein Alignment eya and Eya2

DIOPT Version :9

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_001258891.1
• Gene: Eya2 / 14049
• MGIID: 109341
• Length: 532
• Species: Mus musculus
• Alignment Length: 645
• Identity: 266/645 - (41%)
• Similarity: 349/645 - (54%)
• Gaps: 146/645 - (22%)

  Fly   150 SSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESR- 213
            :|.||||:|.:::.           |...|.:|..:|:...|.:        :.....|||..|
Mouse     6 TSPSLATSSDWSEH-----------GAAVGTLSDREGIAKSAAL--------SVPQLFVKSHPRV 51

  Fly   214 SPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYT 278
            .|||                                :|:|:||         :....|::..|..
Mouse    52 PPGQ--------------------------------SSTAMAA---------YGQTQYSTGIQQA 75

  Fly   279 PPPFYSGYGT--------PYAAAT--AARQAKMEPG----------AAAAAAAYLTPSYAASGNN 323
            ||  |:.|.|        ||:..|  :...:..:.|          |.|..:.|..|.::.:|
Mouse    76 PP--YTAYPTPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAG-- 136

  Fly   324 NSQLYSSPYAGYNNFG----QQDYGGY---YNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVA 381
               ||.......|..|    .|||..|   ...||..|:||:...||.   |:||
Mouse   137 ---LYQGANGLTNTAGFGSVHQDYPSYPSFSQNQYPQYFSPSYNPPYV---PASS---------- 185

  Fly   382 ASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTA 446
                |..||..|  :|.|.|  .:||:    .||.          |:.:.|...|:..|.|. .|
Mouse   186 ----LCSSPLST--STYVLQ--EAPHN----VPSQ----------SSESLAGDYNTHNGPST-PA 227

  Fly   447 GSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLL 511
            ..|..........||. |.|.:|:..|||       .|::|.    |||||||||||:||||:||
Mouse   228 KEGDTERPHRASDGKL-RGRSKRNSDPSP-------AGDNEI----ERVFVWDLDETIIIFHSLL 280

  Fly   512 SGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFA 576
            :|::|:||.||.::.:.|...||||:||:||||.|||::|:|||:|:|||||||||||||.|||:
Mouse   281 TGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFS 345

  Fly   577 TDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQI 641
            ||||| :|.|||  :|||.|||.||||||||||||||::|::||:||.|||.|:|..|||.|||:
Mouse   346 TDGFH-STAPGA--SLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQL 407

  Fly   642 RSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKI 706
            |:|:|..||.|.|.:||.|::|:.|.||||||||:|||.||||||||:|||.:|.|||||||.|.
Mouse   408 RAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKT 472

  Fly   707 GHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL 766
            |.|:|:|||:.|||||:.|:|||||.|||..||..|.||||||.|:|:.||..||::.:|
Mouse   473 GKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	17/71 (24%)
		EYA-cons_domain	492..766	CDD:273739	181/273 (66%)
Eya2	NP_001258891.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..258		19/78 (24%)
		EYA-cons_domain	261..532	CDD:273739	181/277 (65%)
		Hydrolase	263..508	CDD:279092	167/247 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I972
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1736
Isobase	1	0.950	-	0	Normalized mean entropy	S5363
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm44043
orthoMCL	1	0.900	-	-		OOG6_102363
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3984
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.800