Protein Alignment eya and Eya1

DIOPT Version :9

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: XP_006495509.1
• Gene: Eya1 / 14048
• MGIID: 109344
• Length: 609
• Species: Mus musculus
• Alignment Length: 712
• Identity: 277/712 - (38%)
• Similarity: 347/712 - (48%)
• Gaps: 219/712 - (30%)

  Fly    73 SH-SSTVLASNG------PSSAGAGMGVGVGGGGGSGGGVGGGVGQCSPLGLPPQSQPLQPTIGS 130
            || :||.:..||      |.|:.........|...|..|...|....||....|.|.|
Mouse    28 SHINSTSMTPNGTEVKTEPMSSSEIASTAADGSLDSFSGSALGSSSFSPRPAHPFSPP------- 85

  Fly   131 LASLSGHYSNGNANPNV--NSSSCSLA----TASSFAQSAGSSFSTYQQAGGTSG---------G 180
                 ..|.:..:.|::  ..||.::|    |..:......::::||.|.|...|         |
Mouse    86 -----QIYPSNRSYPHILPTPSSQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGISSYGALWAG 145

  Fly   181 VSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDGG 245
            :..|.|:                      |:|:||||          .|...||.|
Mouse   146 IKTESGL----------------------SQSQSPGQ----------TGFLSYGTS--------- 169

  Fly   246 AVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAA---- 306
                                                    :|||            :||.|
Mouse   170 ----------------------------------------FGTP------------QPGQAPYSY 182

  Fly   307 -AAAAAYLTPSYAASGNN---NSQLYSS---PYAGYNNFGQQDYGGYYNEQ-Y-GNYYSPANYSP 362
             ...:::.|.|...||||   ||..::|   .|..|..|||..|..|||.. | .:|.:.:|.||
Mouse   183 QMQGSSFTTSSGLYSGNNSLTNSSGFNSSQQDYPSYPGFGQGQYAQYYNSSPYPAHYMTSSNTSP 247

  Fly   363 YAVSSPSSSASHGHGFHVAASSNLSESPTDTHS---TTPV--HQTTHSPHSPLPISPSTGSGIGP 422
               ::||::|::          .|.|.|:...|   |.|.  :.|.|||.:|:..:.|.....|
Mouse   248 ---TTPSTNATY----------QLQEPPSGVTSQAVTDPTAEYSTIHSPSTPIKETDSERLRRG- 298

  Fly   423 LGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSE 487
                           |.|.|                     |.||||:..|||
Mouse   299 ---------------SDGKS---------------------RGRGRRNNNPSP------------ 315

  Fly   488 AVKPP----ERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFN 548
               ||    ||||:||||||:|:||:||:|||||||.:|..:.:::..|||||:||:||||.|||
Mouse   316 ---PPDSDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFN 377

  Fly   549 EIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGA-PPNLCLPTGVRGGVDWMRKLAFRY 612
            ::|||||||||||||||||||||.|||.||||    |..| ..||||.|||||||||||||||||
Mouse   378 DLEECDQVHIDDVSSDDNGQDLSTYNFGTDGF----PAAATSANLCLATGVRGGVDWMRKLAFRY 438

  Fly   613 RKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTST 677
            |::|:|||:|:.|||.||||.|||||||:|:|||..||:|.|||||.||:|..|.||||:|||:|
Mouse   439 RRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTT 503

  Fly   678 QLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAK 739
            ||.||||||||:|||.:|.|||||||.|||.|:|:|||:.|||||..|||||||.|||..||
Mouse   504 QLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAK 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	13/71 (18%)
		EYA-cons_domain	492..766	CDD:273739	179/253 (71%)
Eya1	XP_006495509.1	HAD_Eya	321..566	CDD:319789	178/249 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1736
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm44043
orthoMCL	1	0.900	-	-		OOG6_102363
Panther	1	1.100	-	-	O	PTHR10190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3984
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.850