DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eya and AgaP_AGAP008726

DIOPT Version :9

Sequence 1:	NP_723188.1	Gene:	eya / 33916	FlyBaseID:	FBgn0000320	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_314837.3	Gene:	AgaP_AGAP008726 / 1275576	VectorBaseID:	AGAP008726	Length:	621	Species:	Anopheles gambiae

Alignment Length:	670	Identity:	374/670 - (55%)
Similarity:	445/670 - (66%)	Gaps:	90/670 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SGHYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATV--MSHW 197
            ||..|.|::...:.....:|||.||.:.|......|      |.|||:........|..  ||||
Mosquito     4 SGGSSAGSSTAGLVDGLSTLATGSSSSSSLVGPLLT------TGGGVATATATTAAAAELGMSHW 62

  Fly   198 THDGTGSSAAVKSESRSPGQVHASLDNGSVAGS--NL-YGCSSASNPLDG--------GAVAV-- 249
            ..|||     ||||.||||     ||...:|.|  || .|.::|::.|||        |..||
Mosquito    63 LSDGT-----VKSELRSPG-----LDANHLAASATNLPLGPATAAHHLDGTGLFCANPGTTAVAT 117

  Fly   250 -------NSSAVAAAAAAVYDGKHDYY-YYNSMQQYTPPPFYSGYG-TPYAAATAARQAKMEPGA 305
                   .|.:.||||..|||.|.||| ||||||||||..:.|.|| |.|.||..|......|.
Mosquito   118 AATLDALQSQSAAAAATNVYDHKSDYYNYYNSMQQYTPAFYSSAYGATAYGAARTASTKIPSPN- 181

  Fly   306 AAAAAAYLTPSY----AASGNNNSQLYSSPYAGYN------NFGQQDYGGYYNEQYGNYY-SPAN 359
                 .||...|    |||.||::|||||  .|||      ..||||...|||:||..|| :.|:
Mosquito   182 -----TYLASPYAAAAAASNNNSAQLYSS--YGYNGSFGQFGAGQQDGYSYYNDQYSPYYANTAS 239

  Fly   360 YSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTP---VHQTTHSPHSPLPISPSTGSGIG 421
            |||| ||||.||.|.. ||||||..: ::||::.|:|||   .|  :|||.||:.|||:.|.|..
Mosquito   240 YSPY-VSSPGSSGSQA-GFHVAAGLS-ADSPSEAHATTPNMLAH--SHSPQSPISISPTAGIGAL 299

  Fly   422 PLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNS 486
            |                     |..|.||..:||||||||:||||||||..||||||:.|:.|.|
Mosquito   300 P---------------------GVGGGGGGISSKTTPTGKSGRARGRRHAHPSPTRSSTSEPGIS 343

  Fly   487 EAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIE 551
            |  |.|||:||||||||:||||:||:||||.||.|:....:.:.:||||::|||||.:||||::|
Mosquito   344 E--KAPERIFVWDLDETIIIFHSLLTGSYAGRYNKNRDHQVQLGYRMEELIFNMADAYFFFNDLE 406

  Fly   552 ECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIK 616
            ||||:|||||:||||||||:.||||.|||||.||.|||||:|||.||||||||||||||||||||
Mosquito   407 ECDQIHIDDVASDDNGQDLNNYNFAADGFHTATPQGAPPNVCLPNGVRGGVDWMRKLAFRYRKIK 471

  Fly   617 DIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAP 681
            |.||:||.|||.||||.||:.|||:||:||..||:|.:|.||||:||:|||||||||||:|||.|
Mosquito   472 DTYNTYRNNVGGLLGPQKRDHWLQVRSDIEHETDSWHSLTLKCLNMIAQRENCVNVLVTTTQLVP 536

  Fly   682 ALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFW 746
            ||||:||:|||.:|.:||:|||:|||.|.|:|||||||||||||||:|||.:||.|||.:|||||
Mosquito   537 ALAKILLYGLGQVFPVENVYSANKIGKEQCFERIVTRFGRKSTYVVVGDGQDEENAAKNLNFPFW 601

  Fly   747 RISAHSDIRALYTALDMGFL 766
            |||:|||||:|:|||:||||
Mosquito   602 RISSHSDIRSLHTALEMGFL 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	32/71 (45%)
eya	NP_723188.1	EYA-cons_domain	492..766	CDD:273739	202/273 (74%)
AgaP_AGAP008726	XP_314837.3	EYA-cons_domain	347..621	CDD:273739	202/273 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	227	1.000	Domainoid score	I5505
eggNOG	1	0.900	-	-		E1_KOG3107
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136572
Inparanoid	1	1.050	668	1.000	Inparanoid score	I2021
OMA	1	1.010	-	-		QHG26635
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm51060
Panther	1	1.100	-	-	LDO	PTHR10190
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X642
TreeFam	1	0.960	-	-
	12	11.930