DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eya and eya4

DIOPT Version :9

Sequence 1:	NP_723188.1	Gene:	eya / 33916	FlyBaseID:	FBgn0000320	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_031758272.1	Gene:	eya4 / 100487615	XenbaseID:	XB-GENE-485487	Length:	654	Species:	Xenopus tropicalis

Alignment Length:	720	Identity:	284/720 - (39%)
Similarity:	371/720 - (51%)	Gaps:	184/720 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 LASLSGHYSNGNAN-------PNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVV 188
            |||.....|:|:.:       .|:||:|.                        |:.|..||:
Frog    35 LASPHNRVSSGDTSGASKLDKANINSTSI------------------------TTNGTGGEN--- 72

  Fly   189 GGATVMSHWTHD-----GTGSSA--------------AVKSESRSPGQV-----HASLD--NGSV 227
              .||::  |.|     ||.|:|              |||:|..:..:.     ..|||  .|||
Frog    73 --MTVLN--TADWLLSCGTPSAATSMDSYSTLHVSLLAVKTEPMNNSETATTTGDGSLDTFTGSV 133

  Fly   228 AGSNLYGCSSA---------SNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFY 283
            ..|:.|...||         |.|...     ..|..||...:.|.|:..   |:.|||.|....|
Frog   134 ITSSGYSPRSAHQYSPQLYPSKPYPH-----ILSTPAAQTMSAYGGQSQ---YSGMQQPTVYTAY 190

  Fly   284 SGYGTPYAAAT----------------AARQAKMEPGAAAAAAAYLTP-------SYAASGNN-- 323
            |..|.||:..|                :..|:.::....:.:..:..|       ||...|::
Frog   191 SQTGQPYSLPTYDLGVMLPGIKTESGLSQTQSPLQSACLSYSPGFSPPQPGQTPYSYQMPGSSFP 255

  Fly   324 -NSQLY-SSPYAGYNNF--GQQDYGGYY---NEQYGNYYSPANYSPY-----AVSSPSSSASHGH 376
             :|.:| ::..:...||  .||||..|.   ..||..|||.:.|..|     .|...|||:|
Frog   256 PSSSIYANNSVSNSTNFTNAQQDYPSYTAFGQNQYPQYYSASTYGTYMTQNNTVDGTSSSSS--- 317

  Fly   377 GFHVAAS-SNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGG 440
            .:.:..| |.|:..| .|...|.......||.:|                         :.....
Frog   318 TYQLQDSLSGLTTQP-GTDLQTGEFDAVQSPSTP-------------------------IKDLDD 356

  Fly   441 SSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPP----ERVFVWDLD 501
            .:..||||             ..|.|||:: .|||               ||    ||||:||||
Frog   357 RTCRTAGS-------------KSRGRGRKN-NPSP---------------PPDSDLERVFIWDLD 392

  Fly   502 ETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDN 566
            ||:||||:||:|::|.:|.||..:.:|:..|||||:||:||.|.|||::|||||||:||||||||
Frog   393 ETIIIFHSLLTGTFAQKYGKDSPTAVTLGLRMEEMIFNLADAHLFFNDLEECDQVHVDDVSSDDN 457

  Fly   567 GQDLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLG 631
            |||||:|:||||||..   ..:...||||||||||||||||||||||::|::||:|:.|||.|.|
Frog   458 GQDLSSYSFATDGFRA---AASSTTLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLFG 519

  Fly   632 PGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFN 696
            |.|||||||:|:::||.||:|.:.|||.||:||.|.|.||||||:|||.|||:||||:.|||:|.
Frog   520 PAKREAWLQLRADLEVLTDSWLSNALKSLSLISTRSNSVNVLVTTTQLIPALSKVLLYSLGGVFP 584

  Fly   697 IENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTAL 761
            |||||||.|:|.|:|:|||:.|||||..|||||||.|||.|||..|.||||||:|||:.||:.||
Frog   585 IENIYSATKVGKESCFERIIQRFGRKVVYVVIGDGVEEEQAAKKNNMPFWRISSHSDLLALHQAL 649

  Fly   762 DMGFL 766
            ::.:|
Frog   650 ELEYL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	DUF3682	413..>485	CDD:289231	11/71 (15%)
eya	NP_723188.1	EYA-cons_domain	492..766	CDD:273739	183/277 (66%)
eya4	XP_031758272.1	Herpes_BLLF1	<42..>381	CDD:282904	98/435 (23%)
eya4	XP_031758272.1	HAD_Eya	383..654	CDD:319789	182/273 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I973
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1706
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000834
OrthoInspector	1	1.000	-	-		otm49218
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X642
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.050